7MQS
The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (E, F) | Isoform Short of Insulin receptor | polymer | 916 | 104632.7 | 2 | UniProt (P06213-2) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) UniProt (by SIFTS) (P06213) | Homo sapiens (Human) | IR |
| 2 | C, E, G (A, C, G) | Insulin A chain | polymer | 24 | 2736.1 | 3 | UniProt (P01308) | Homo sapiens | |
| 3 | D, F, H (B, D, H) | Insulin B chain | polymer | 22 | 2538.0 | 3 | UniProt (P01308) | Homo sapiens |
Sequence modifications
A, C, G: 1 - 21 (UniProt: P01308)
B, D, H: 1 - 22 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| His 21 | Asn 110 | engineered mutation |
| Ser 22 | - | insertion |
| Leu 23 | - | insertion |
| Gln 24 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Glu 10 | His 34 | engineered mutation |
| Leu 20 | Gly 44 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 225087.6 | |
| All* | Total formula weight | 225087.6 |
