4A9Y

P38ALPHA MAP KINASE BOUND TO CMPD 8

Summary for 4A9Y

• Entry DOI: 10.2210/pdb4a9y/pdb
• Related: 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2I0H 2Y8O 2YIS 2YIW 2YIX 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA
• Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 42624.56

Authors

Gerhardt, S.,Hargreaves, D. (deposition date: 2011-11-29, release date: 2012-05-16, Last modification date: 2019-02-06)

• Primary citation: Brown, D.S.,Cumming, J.G.,Bethel, P.,Finlayson, J.,Gerhardt, S.,Nash, I.,Pauptit, R.,Pike, K.G.,Reid, A.,Snelson, W.,Swallow, S.,Thompson, C.; The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases; Bioorg.Med.Chem.Lett., 22:3879-, 2012; PubMed: 22608965; DOI: 10.1016/J.BMCL.2012.04.116

Experimental method

X-RAY DIFFRACTION (2.2 Å)