1WBN

fragment based p38 inhibitors

Summary for 1WBN

• Entry DOI: 10.2210/pdb1wbn/pdb
• Related: 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZZ2 1ZZL
• Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA (3 entities in total)
• Functional Keywords: p38 map kinase, inhibitor structure, alternative splicing, atp-binding, nuclear protein, phosphorylation, serine/threonine protein kinase, transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 1
• Total formula weight: 41743.07

Authors

Cleasby, A.,Devine, L.A.,Gill, A.L.,Jhoti, H. (deposition date: 2004-11-04, release date: 2005-11-03, Last modification date: 2011-07-13)

• Primary citation: Gill, A.L.,Frederickson, M.,Cleasby, A.,Woodhead, S.J.,Carr, M.G.,Woodhead, A.J.,Walker, M.T.,Congreve, M.S.,Devine, L.A.,Tisi, D.,O'Reilly, M.,Seavers, L.C.,Davis, D.J.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.W.,Carr, R.A.,Jhoti, H.; Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation.; J.Med.Chem., 48:414-, 2005; PubMed: 15658855; DOI: 10.1021/JM049575N

Experimental method

X-RAY DIFFRACTION (2.4 Å)