1W84
p38 Kinase crystal structure in complex with small molecule inhibitor
Summary for 1W84
| Entry DOI | 10.2210/pdb1w84/pdb |
| Related | 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W83 1W84 1WFC |
| Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 14, 3-(2-PYRIDIN-4-YLETHYL)-1H-INDOLE (3 entities in total) |
| Functional Keywords | kinase/inhibitor, kinase-inhibitor complex, p38, kinase, inhibitor complex |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cytoplasm : Q16539 |
| Total number of polymer chains | 1 |
| Total formula weight | 41565.48 |
| Authors | Tickle, J.,Jhoti, H.,Cleasby, A.,Devine, L. (deposition date: 2004-09-16, release date: 2005-02-08, Last modification date: 2018-01-31) |
| Primary citation | Gill, A.L.,Frederickson, M.,Cleasby, A.,Woodhead, S.J.,Carr, M.G.,Woodhead, A.J.,Walker, M.T.,Congreve, M.S.,Devine, L.A.,Tisi, D.,O'Reilly, M.,Seavers, L.C.,Davis, D.J.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.W.,Carr, R.A.,Jhoti, H. Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. J. Med. Chem., 48:414-426, 2005 Cited by PubMed: 15658855DOI: 10.1021/jm049575n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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