1W84

p38 Kinase crystal structure in complex with small molecule inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	ROTATING ANODE
Temperature [K]	100
Spacegroup name	P 21 21 21
Unit cell lengths	45.639, 86.604, 124.921
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	19.570 - 2.200
R-factor	0.182
Rwork	0.179
R-free	0.23800
Structure solution method	OTHER
RMSD bond length	0.013
RMSD bond angle	1.592
Refinement software	REFMAC (5.2.0003A)

Data quality characteristics

	Overall
Low resolution limit [Å]	50.000
High resolution limit [Å]	2.200
Rmerge	0.070
Number of reflections	24207
<I/σ(I)>	12.5
Completeness [%]	93.9
Redundancy	2.3

Crystallization Conditions

crystal ID	method	pH	temperature	details
1