1M7Q

Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor

Summary for 1M7Q

• Entry DOI: 10.2210/pdb1m7q/pdb
• Descriptor: Mitogen-activated protein kinase 14, SULFATE ION, 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE, ... (4 entities in total)
• Functional Keywords: serine/threonine kinase, atp-binding domain, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q16539
• Total number of polymer chains: 1
• Total formula weight: 42584.35

Authors

Stelmach, J.E.,Liu, L.,Patel, S.B.,Pivnichny, J.V.,Scapin, G.,Singh, S.,Hop, C.E.C.A.,Wang, Z.,Cameron, P.M.,Nichols, E.A.,O'Keefe, S.J.,O'Neill, E.A.,Schmatz, D.M.,Schwartz, C.D.,Thompson, C.M.,Zaller, D.M.,Doherty, J.B. (deposition date: 2002-07-22, release date: 2002-12-11, Last modification date: 2024-02-14)

• Primary citation: Stelmach, J.E.,Liu, L.,Patel, S.B.,Pivnichny, J.V.,Scapin, G.,Singh, S.,Hop, C.E.,Wang, Z.,Strauss, J.R.,Cameron, P.M.,Nichols, E.A.,O'Keefe, S.J.,O'Neill, E.A.,Schmatz, D.M.,Schwartz, C.D.,Thompson, C.M.,Zaller, D.M.,Doherty, J.B.; Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.; Bioorg.Med.Chem.Lett., 13:277-280, 2003; PubMed: 12482439; DOI: 10.1016/S0960-894X(02)00752-7

Experimental method

X-RAY DIFFRACTION (2.4 Å)