1M7Q
Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 14 | polymer | 366 | 41998.9 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (human) | Mitogen-activated protein kinase p38, MAP kinase p38, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2 |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE | non-polymer | 489.3 | 1 | Chemie (DQO) | |||
| 4 | water | water | 18.0 | 114 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | insertion |
| Ser -4 | - | insertion |
| His -3 | - | insertion |
| Met -2 | - | insertion |
| Leu -1 | - | insertion |
| Glu 0 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41998.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 585.4 | |
| All* | Total formula weight | 42584.3 |
