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1KV2

Human p38 MAP Kinase in Complex with BIRB 796

Summary for 1KV2
Entry DOI10.2210/pdb1kv2/pdb
Related1IAN 1KV1
Descriptorp38 MAP kinase, 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA (2 entities in total)
Functional Keywordsprotein-inhibitor complex, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity): Q16539
Total number of polymer chains1
Total formula weight41870.85
Authors
Pargellis, C.,Tong, L.,Churchill, L.,Cirillo, P.F.,Gilmore, T.,Graham, A.G.,Grob, P.M.,Hickey, E.R.,Moss, N.,Pav, S.,Regan, J. (deposition date: 2002-01-23, release date: 2002-03-27, Last modification date: 2024-02-14)
Primary citationPargellis, C.,Tong, L.,Churchill, L.,Cirillo, P.F.,Gilmore, T.,Graham, A.G.,Grob, P.M.,Hickey, E.R.,Moss, N.,Pav, S.,Regan, J.
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
Nat.Struct.Biol., 9:268-272, 2002
Cited by
PubMed: 11896401
DOI: 10.1038/nsb770
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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