1OUY
The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor
Summary for 1OUY
Entry DOI | 10.2210/pdb1ouy/pdb |
Related | 1M7Q 1OUK 1OVE |
Descriptor | Mitogen-activated protein kinase 14, 1-(2,6-DICHLOROPHENYL)-6-[(2,4-DIFLUOROPHENYL)SULFANYL]-7-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-3,4-DIHYDROPYRIDO[3,2-D]PYRIMIDIN-2(1H)-ONE (3 entities in total) |
Functional Keywords | map kinase, hydrophobic pocket, kinase domain, atp binding domain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42518.33 |
Authors | Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G. (deposition date: 2003-03-25, release date: 2003-09-02, Last modification date: 2023-08-16) |
Primary citation | Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G. Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Nat.Struct.Biol., 10:764-769, 2003 Cited by PubMed: 12897767DOI: 10.1038/nsb949 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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