1OUY

The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor

Summary for 1OUY

Entry DOI	10.2210/pdb1ouy/pdb
Related	1M7Q 1OUK 1OVE
Descriptor	Mitogen-activated protein kinase 14, 1-(2,6-DICHLOROPHENYL)-6-[(2,4-DIFLUOROPHENYL)SULFANYL]-7-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-3,4-DIHYDROPYRIDO[3,2-D]PYRIMIDIN-2(1H)-ONE (3 entities in total)
Functional Keywords	map kinase, hydrophobic pocket, kinase domain, atp binding domain, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	42518.33
Authors	Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G. (deposition date: 2003-03-25, release date: 2003-09-02, Last modification date: 2023-08-16)
Primary citation	Fitzgerald, C.E.,Patel, S.B.,Becker, J.W.,Cameron, P.M.,Zaller, D.,Pikounis, V.B.,O'Keefe, S.J.,Scapin, G. Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Nat.Struct.Biol., 10:764-769, 2003 Cited by PubMed: 12897767 DOI: 10.1038/nsb949 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation