1OUY
The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 366 | 41998.9 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | Mitogen-activated protein kinase p38alpha, MAP kinase p38alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | B (A) | 1-(2,6-DICHLOROPHENYL)-6-[(2,4-DIFLUOROPHENYL)SULFANYL]-7-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-3,4-DIHYDROPYRIDO[3,2-D]PYRIMIDIN-2(1H)-ONE | non-polymer | 519.4 | 1 | Chemie (094) | |||
| 3 | C (A) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | cloning artifact |
| Ser -4 | - | cloning artifact |
| His -3 | - | cloning artifact |
| Met -2 | - | cloning artifact |
| Leu -1 | - | cloning artifact |
| Glu 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41998.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 519.4 | |
| All* | Total formula weight | 42518.3 |
