1ZZ2

Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes

Summary for 1ZZ2

Entry DOI	10.2210/pdb1zz2/pdb
Related	1ZYJ
Descriptor	Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, N-[3-(4-FLUOROPHENOXY)PHENYL]-4-[(2-HYDROXYBENZYL)AMINO]PIPERIDINE-1-SULFONAMIDE, ... (4 entities in total)
Functional Keywords	protein-inhibitor complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	42107.11
Authors	Michelotti, E.L.,Moffett, K.K.,Springman, E.B.,Karpusas, M. (deposition date: 2005-06-13, release date: 2005-10-18, Last modification date: 2024-02-14)
Primary citation	Michelotti, E.L.,Moffett, K.K.,Nguyen, D.,Kelly, M.J.,Shetty, R.,Chai, X.,Northrop, K.,Namboodiri, V.,Campbell, B.,Flynn, G.A.,Fujimoto, T.,Hollinger, F.P.,Bukhtiyarova, M.,Springman, E.B.,Karpusas, M. Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg.Med.Chem.Lett., 15:5274-5279, 2005 Cited by PubMed: 16169718 DOI: 10.1016/j.bmcl.2005.08.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation