3ZS5
Structural basis for kinase selectivity of three clinical p38alpha inhibitors
Summary for 3ZS5
Entry DOI | 10.2210/pdb3zs5/pdb |
Related | 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2I0H 2Y8O 2YIS 2YIW 2YIX 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC |
Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 14, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, octyl beta-D-glucopyranoside, ... (5 entities in total) |
Functional Keywords | transferase, tak-715, scio-469, vx-745, sb-203580 |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 42642.65 |
Authors | Azevedo, R.,van Zeeland, M.,Raaijmakers, H.C.A.,Kazemier, B.,Oubrie, A. (deposition date: 2011-06-23, release date: 2012-07-04, Last modification date: 2024-05-08) |
Primary citation | Azevedo, R.,van Zeeland, M.,Raaijmakers, H.,Kazemier, B.,de Vlieg, J.,Oubrie, A. X-ray structure of p38 alpha bound to TAK-715: comparison with three classic inhibitors. Acta Crystallogr. D Biol. Crystallogr., 68:1041-1050, 2012 Cited by PubMed: 22868770DOI: 10.1107/S090744491201997X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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