2I0H

The structure of p38alpha in complex with an arylpyridazinone

Summary for 2I0H

Entry DOI	10.2210/pdb2i0h/pdb
Descriptor	Mitogen-activated protein kinase 14, 2-(3-{(2-CHLORO-4-FLUOROPHENYL)[1-(2-CHLOROPHENYL)-6-OXO-1,6-DIHYDROPYRIDAZIN-3-YL]AMINO}PROPYL)-1H-ISOINDOLE-1,3(2H)-DIONE, GLYCEROL, ... (4 entities in total)
Functional Keywords	serine/threonine kinase, inhibitor design, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	43241.80
Authors	Natarajan, S.R.,Heller, S.T.,Nam, K.,Singh, S.B.,Scapin, G.,Patel, S.,Thompson, J.E.,Fitzgerald, C.E.,O'Keefe, S.J. (deposition date: 2006-08-10, release date: 2006-10-17, Last modification date: 2023-08-30)
Primary citation	Natarajan, S.R.,Heller, S.T.,Nam, K.,Singh, S.B.,Scapin, G.,Patel, S.,Fitzgerald, C.E.,Thompson, J.E.,O'Keefe, S.J. p38 MAP Kinase Inhibitors Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design. Bioorg.Med.Chem.Lett., 16:5809-5813, 2006 Cited by PubMed: 16945533 DOI: 10.1016/j.bmcl.2006.08.074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation