2BAL

p38alpha MAP kinase bound to pyrazoloamine

Summary for 2BAL

Entry DOI	10.2210/pdb2bal/pdb
Related	2BAJ 2BAK 2BAQ
Descriptor	Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE (3 entities in total)
Functional Keywords	p38, map kinase, serine/threonine kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	42453.36
Authors	Gerhardt, S.,Pauptit, R.A.,Read, J.,Tucker, J.,Norman, R.A.,Breed, J. (deposition date: 2005-10-14, release date: 2005-12-06, Last modification date: 2011-07-13)
Primary citation	Sullivan, J.E.,Holdgate, G.A.,Campbell, D.,Timms, D.,Gerhardt, S.,Breed, J.,Breeze, A.L.,Bermingham, A.,Pauptit, R.A.,Norman, R.A.,Embrey, K.J.,Read, J.,Vanscyoc, W.S.,Ward, W.H. Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44:16475-16490, 2005 Cited by PubMed: 16342939 DOI: 10.1021/bi051714v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation