3ZSH

X-ray structure of p38alpha bound to SCIO-469

Summary for 3ZSH

Entry DOI	10.2210/pdb3zsh/pdb
Related	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2I0H 2Y8O 2YIS 2YIW 2YIX 3ZS5 3ZSG 3ZSI
Descriptor	MITOGEN-ACTIVATED PROTEIN KINASE 14, 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	42299.65
Authors	Azevedo, R.,van Zeeland, M.,Raaijmakers, H.,Kazemier, B.,Oubrie, A. (deposition date: 2011-06-28, release date: 2012-06-13, Last modification date: 2020-07-29)
Primary citation	Azevedo, R.,van Zeeland, M.,Raaijmakers, H.,Kazemier, B.,de Vlieg, J.,Oubrie, A. X-ray structure of p38 alpha bound to TAK-715: comparison with three classic inhibitors. Acta Crystallogr. D Biol. Crystallogr., 68:1041-1050, 2012 Cited by PubMed: 22868770 DOI: 10.1107/S090744491201997X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation