PDB: 56 resultsInfo pagesStatus searchChemie searchBIRD

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5EPM	Ceratotoxin variant in complex with specific antibody Fab fragment Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, Beta-theraphotoxin-Cm1a Authors: Strop, P, Shcherbatko, A, Rossi, A. Deposit date: 2015-11-11 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain. J.Biol.Chem., 291, 2016
6AV8	Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox Descriptor: U5-theraphotoxin-Hs1b 1 Authors: Gewe, M.M, Rupert, P, Strong, R.K. Deposit date: 2017-09-01 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat. Struct. Mol. Biol., 25, 2018
6W6O	NaChBac-Nav1.7VSDII chimera and HWTX-IV complex Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Huwentoxin-IV, NaChBac-Nav1.7VSDII chimera Authors: Yan, N, Gao, S. Deposit date: 2020-03-17 Release date: 2020-06-24 Last modified: 2021-01-13 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc. Proc.Natl.Acad.Sci.USA, 117, 2020
7K48	Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV Descriptor: Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a Authors: Wisedchaisri, G, Tonggu, L, Gamal El-Din, T.M, McCord, E, Zheng, N, Catterall, W.A. Deposit date: 2020-09-15 Release date: 2020-12-02 Last modified: 2021-01-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin. Mol.Cell, 81, 2021
3J5Q	Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy Descriptor: Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1 Authors: Liao, M, Cao, E, Julius, D, Cheng, Y. Deposit date: 2013-10-28 Release date: 2013-12-04 Last modified: 2022-11-02 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: TRPV1 structures in distinct conformations reveal activation mechanisms. Nature, 504, 2013
6MK5	Solution NMR structure of spider toxin analogue [F5A,M6F,T26L,K28R]GpTx-1 Descriptor: Toxin GTx1-15 Authors: Schroeder, C.I. Deposit date: 2018-09-25 Release date: 2018-12-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1. ACS Chem. Biol., 14, 2019
2M4Z	Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a). Descriptor: Mu-theraphotoxin-Hh2a Authors: Gibbs, A. Deposit date: 2013-02-12 Release date: 2013-06-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a). J.Biol.Chem., 288, 2013
1NIY	THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-IV BY 2D 1H-NMR Descriptor: HAINANTOXIN-IV Authors: Li, D, Lu, S, Gu, X, Liang, S. Deposit date: 2002-12-30 Release date: 2003-01-14 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Structure-Activity Relationships of Hainantoxin-IV and Structure Determination of Active and Inactive Sodium Channel Blockers. J.Biol.Chem., 279, 2004
1NIX	THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR Descriptor: HAINANTOXIN-I Authors: Li, D, Liang, S. Deposit date: 2002-12-29 Release date: 2003-01-14 Last modified: 2017-11-29 Method: SOLUTION NMR Cite: Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. Febs Lett., 555, 2003
2M9L	Solution structure of protoxin-1 Descriptor: Beta-theraphotoxin-Tp1a Authors: Daly, N. Deposit date: 2013-06-13 Release date: 2014-04-30 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. Curr.Biol., 24, 2014
2M50	Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a). Descriptor: Mu-theraphotoxin-Hh2a Authors: Gibbs, A, Minassian, N, Flinspach, M, Wickenden, A. Deposit date: 2013-02-12 Release date: 2013-06-19 Last modified: 2023-11-29 Method: SOLUTION NMR Cite: Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a). J.Biol.Chem., 288, 2013
1D1H	SOLUTION STRUCTURE OF HANATOXIN 1 Descriptor: HANATOXIN TYPE 1 Authors: Takahashi, H, Kim, J.I, Sato, K, Swartz, K.J, Shimada, I. Deposit date: 1999-09-16 Release date: 2000-09-20 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins. J.Mol.Biol., 297, 2000
1ZJQ	Solution structure of Jingzhaotoxin-VII Descriptor: Jingzhaotoxin-VII Authors: Liao, Z. Deposit date: 2005-04-30 Release date: 2005-05-24 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Solution structure of Jingzhaotoxin-VII TO BE PUBLISHED
2M4X	Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a). Descriptor: Mu-theraphotoxin-Hh2a Authors: Gibbs, A, Flinspach, M. Deposit date: 2013-02-11 Release date: 2013-06-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a). J.Biol.Chem., 288, 2013
8FD4	Solution structure of mu-theraphotoxin Cg4a from Chinese tarantula Chilobrachys jingzhao Descriptor: Jingzhaotoxin F7-10.36 Authors: Sharma, G, Jia, X, Chin, Y.K.Y, Mobli, M. Deposit date: 2022-12-01 Release date: 2023-11-08 Method: SOLUTION NMR Cite: Solution structure of mu-theraphotoxin Cg4a from Chinese tarantula Chilobrachys jingzhao To Be Published
5TLR	Solution NMR structure of gHwTx-IV Descriptor: Mu-theraphotoxin-Hs2a Authors: Agwa, A.J, Schroeder, C.I. Deposit date: 2016-10-11 Release date: 2017-02-22 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochim. Biophys. Acta, 1859, 2017
5T3M	Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7 Descriptor: Mu-theraphotoxin-Hs2a Authors: Rahnama, S, Sharma, G, Mobli, M. Deposit date: 2016-08-25 Release date: 2017-09-06 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant. PLoS ONE, 12, 2017
2MT7	Solution structure of spider-venom peptide Hs1a Descriptor: Hs1a Authors: Klint, J.K, King, G.F, Mobli, M. Deposit date: 2014-08-14 Release date: 2015-08-19 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Nav1.7 inhibitors normalise mechanical responses in chronic visceral hypersensitivity To be Published
2N1N	Solution structure of VSTx1 Descriptor: Kappa-theraphotoxin-Gr3a Authors: Lau, H.Y, King, G.F, Mobli, M. Deposit date: 2015-04-12 Release date: 2016-03-02 Last modified: 2016-10-12 Method: SOLUTION NMR Cite: Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels. Sci Rep, 6
2MPQ	Solution structure of the sodium channel toxin Hd1a Descriptor: Hd1a Authors: Klint, J.K, Mobli, M, King, G.F. Deposit date: 2014-06-01 Release date: 2015-03-25 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. Br.J.Pharmacol., 172, 2015
2MQF	NMR structure of spider toxin-TRTX-Hhn2b Descriptor: Mu-theraphotoxin-Hhn2b Authors: Klint, J.K, Chin, Y.K.Y, Mobli, M. Deposit date: 2014-06-19 Release date: 2015-07-15 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7 Mol.Pharmacol., 88, 2015
2MXM	NMR solution structure of TRTX-Tp1a from the tarantula Thrixopelma pruriens Descriptor: entity Authors: Rosengren, K. Deposit date: 2015-01-08 Release date: 2015-06-03 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Identification and Characterization of ProTx-III [ mu-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol.Pharmacol., 88, 2015
1TYK	SOLUTION STRUCTURE OF A TOXIN FROM THE TARANTULA, GRAMMOSTOLA SPATULATA, WHICH INHIBITS MECHANOSENSITIVE ION CHANNELS Descriptor: Toxin GsMTx-4 Authors: Oswald, R.E, Suchyna, T.M, Mcfeeters, R, Gottlieb, P, Sachs, F. Deposit date: 2004-07-08 Release date: 2004-07-13 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Solution Structure of Peptide Toxins that Block Mechanosensitive Ion Channels J.Biol.Chem., 277, 2002
2N6O	Structure of spider-venom peptide Hm1a Descriptor: Kappa-theraphotoxin-Hm1a Authors: Undheim, E.A.B, King, G.F, Mobli, M. Deposit date: 2015-08-27 Release date: 2016-09-07 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structure of spider-venom peptide Hm1a To be Published
6V6T	Solution structure of delta-theraphotoxin-Hm1b from Heteroscodra maculata Descriptor: Delta-theraphotoxin-Hm1b Authors: Chin, Y.K.Y, Chow, C.Y, King, G.F. Deposit date: 2019-12-05 Release date: 2020-05-13 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: A selective Na V 1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem Pharmacol, 181, 2020

 

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