6MK5

Solution NMR structure of spider toxin analogue [F5A,M6F,T26L,K28R]GpTx-1

Summary for 6MK5

• Entry DOI: 10.2210/pdb6mk5/pdb
• NMR Information: BMRB: 30522
• Descriptor: Toxin GTx1-15 (1 entity in total)
• Functional Keywords: gptx-1 analogue, spider toxin, peptide-membrane interactions, voltage-sensitive sodium channels, toxin
• Biological source: Grammostola porteri (Tarantula spider)
• Total number of polymer chains: 1
• Total formula weight: 4068.86

Authors

Schroeder, C.I. (deposition date: 2018-09-25, release date: 2018-12-19, Last modification date: 2023-06-14)

• Primary citation: Lawrence, N.,Wu, B.,Ligutti, J.,Cheneval, O.,Agwa, A.J.,Benfield, A.H.,Biswas, K.,Craik, D.J.,Miranda, L.P.,Henriques, S.T.,Schroeder, C.I.; Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1.; ACS Chem. Biol., 14:118-130, 2019; PubMed: 30507158; DOI: 10.1021/acschembio.8b00989

Experimental method

SOLUTION NMR