6MK5

Solution NMR structure of spider toxin analogue [F5A,M6F,T26L,K28R]GpTx-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005246	molecular_function	calcium channel regulator activity
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity
A	0017080	molecular_function	sodium channel regulator activity
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS60021
Number of Residues	29
Details	HWTX_1 Huwentoxin-1 family signature. CLgAfrkCipdndkCCrpnlv.CsrlhRWC

Chain	Residue	Details
A	CYS2-CYS30

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Important for activity and sodium channel selectivity => ECO:0000305|PubMed:25658507

Chain	Residue	Details
A	ALA5
A	LEU26
A	ARG28

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site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Important for activity => ECO:0000305|PubMed:25658507

Chain	Residue	Details
A	PHE6
A	HIS27
A	TRP29
A	LYS31
A	TYR32
A	PHE34

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phenylalanine amide => ECO:0000269|PubMed:25658507

Chain	Residue	Details
A	PHE34

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