2MPQ

Solution structure of the sodium channel toxin Hd1a

Summary for 2MPQ

Entry DOI	10.2210/pdb2mpq/pdb
NMR Information	BMRB: 19998
Descriptor	Hd1a (1 entity in total)
Functional Keywords	spider toxin, disulfide-rich peptide, sodium channel, knottin, inhibitor cystine knot, toxin
Biological source	Haplopelma doriae
Total number of polymer chains	1
Total formula weight	3891.48
Authors	Klint, J.K.,Mobli, M.,King, G.F. (deposition date: 2014-06-01, release date: 2015-03-25, Last modification date: 2024-11-27)
Primary citation	Klint, J.K.,Smith, J.J.,Vetter, I.,Rupasinghe, D.B.,Er, S.Y.,Senff, S.,Herzig, V.,Mobli, M.,Lewis, R.J.,Bosmans, F.,King, G.F. Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. Br.J.Pharmacol., 172:2445-2458, 2015 Cited by PubMed Abstract: Chronic pain is a serious worldwide health issue, with current analgesics having limited efficacy and dose-limiting side effects. Humans with loss-of-function mutations in the voltage-gated sodium channel NaV 1.7 (hNaV 1.7) are indifferent to pain, making hNaV 1.7 a promising target for analgesic development. Since spider venoms are replete with NaV channel modulators, we examined their potential as a source of hNaV 1.7 inhibitors. PubMed: 25754331 DOI: 10.1111/bph.13081 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation