2M50
Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).
Summary for 2M50
Entry DOI | 10.2210/pdb2m50/pdb |
Related | 2M4X 2M4Z |
NMR Information | BMRB: 19032 |
Descriptor | Mu-theraphotoxin-Hh2a (1 entity in total) |
Functional Keywords | venom toxin, toxin |
Biological source | Haplopelma schmidti (Chinese bird spider,Chinese golden earth tiger) |
Cellular location | Secreted: P83303 |
Total number of polymer chains | 1 |
Total formula weight | 4062.76 |
Authors | Gibbs, A.,Minassian, N.,Flinspach, M.,Wickenden, A. (deposition date: 2013-02-12, release date: 2013-06-19, Last modification date: 2023-11-29) |
Primary citation | Minassian, N.A.,Gibbs, A.,Shih, A.Y.,Liu, Y.,Neff, R.A.,Sutton, S.W.,Mirzadegan, T.,Connor, J.,Fellows, R.,Husovsky, M.,Nelson, S.,Hunter, M.J.,Flinspach, M.,Wickenden, A.D. Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a). J.Biol.Chem., 288:22707-22720, 2013 Cited by PubMed: 23760503DOI: 10.1074/jbc.M113.461392 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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