Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).

Summary for 2M4Z

Related2M4X 2M50
DescriptorMu-theraphotoxin-Hh2a (1 entity in total)
Functional Keywordsvenom toxin, toxin
Biological sourceHaplopelma schmidti (Chinese bird spider,Chinese golden earth tiger)
Cellular locationSecreted P83303
Total number of polymer chains1
Total molecular weight4005.73
Gibbs, A. (deposition date: 2013-02-12, release date: 2013-06-19, Last modification date: 2013-08-28)
Primary citation
Minassian, N.A.,Gibbs, A.,Shih, A.Y.,Liu, Y.,Neff, R.A.,Sutton, S.W.,Mirzadegan, T.,Connor, J.,Fellows, R.,Husovsky, M.,Nelson, S.,Hunter, M.J.,Flinspach, M.,Wickenden, A.D.
Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a).
J.Biol.Chem., 288:22707-22720, 2013
PubMed: 23760503 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M113.461392
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers307.2%35.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-08-05