Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).

Summary for 2M4X

Related2M4Z 2M50
DescriptorMu-theraphotoxin-Hh2a (1 entity in total)
Functional Keywordsvenom, toxin
Biological sourceHaplopelma schmidti (Chinese bird spider,Chinese golden earth tiger)
Cellular locationSecreted P83303
Total number of polymer chains1
Total molecular weight4120.87
Gibbs, A.,Flinspach, M. (deposition date: 2013-02-11, release date: 2013-06-19, Last modification date: 2013-08-28)
Primary citation
Minassian, N.A.,Gibbs, A.,Shih, A.Y.,Liu, Y.,Neff, R.A.,Sutton, S.W.,Mirzadegan, T.,Connor, J.,Fellows, R.,Husovsky, M.,Nelson, S.,Hunter, M.J.,Flinspach, M.,Wickenden, A.D.
Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( mu-TRTX-Hh2a).
J.Biol.Chem., 288:22707-22720, 2013
PubMed: 23760503 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M113.461392
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers107.0%21.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures