2M4X

Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS60021
Number of Residues	30
Details	HWTX_1 Huwentoxin-1 family signature. CLeIfkaCnpsndqCCkssklvCsrktRWC

Chain	Residue	Details
A	CYS2-CYS31

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Site: {"description":"Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A)","evidences":[{"source":"PubMed","id":"23760503","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid (Glu); partial","evidences":[{"source":"PubMed","id":"23826086","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Isoleucine amide","evidences":[{"source":"PubMed","id":"12228241","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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