Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy

Summary for 3J5Q

Related3J5P 3J5R
EMDB information5776 5777 5778
DescriptorTransient receptor potential cation channel subfamily V member 1, Double-knot toxin (2 entities in total)
Functional Keywordstrpv1 channel, dktx, rtx, transport protein-toxin complex, transport protein/toxin
Biological sourceRattus norvegicus (rat)
Total number of polymer chains8
Total molecular weight283593.68
Liao, M.,Cao, E.,Julius, D.,Cheng, Y. (deposition date: 2013-10-28, release date: 2013-12-04, Last modification date: 2018-07-18)
Primary citation
Cao, E.,Liao, M.,Cheng, Y.,Julius, D.
TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504:113-118, 2013
PubMed: 24305161 (PDB entries with the same primary citation)
DOI: 10.1038/nature12823
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers104 0.5% 28.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
PDB entries from 2020-10-21