3J5Q

Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy

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Functional Information from GO Data

ChainGOidnamespacecontents
B0030054cellular_componentcell junction
B0005829cellular_componentcytosol
B0030425cellular_componentdendrite
B0032591cellular_componentdendritic spine membrane
B0009897cellular_componentexternal side of plasma membrane
B0016021cellular_componentintegral component of membrane
B0005887cellular_componentintegral component of plasma membrane
B0031226cellular_componentintrinsic component of plasma membrane
B0016020cellular_componentmembrane
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0005886cellular_componentplasma membrane
B0045211cellular_componentpostsynaptic membrane
B0045202cellular_componentsynapse
B0005524molecular_functionATP binding
B0005262molecular_functioncalcium channel activity
B0015278molecular_functioncalcium-release channel activity
B0005516molecular_functioncalmodulin binding
B0005261molecular_functioncation channel activity
B0008324molecular_functioncation transmembrane transporter activity
B0017081molecular_functionchloride channel regulator activity
B0005231molecular_functionexcitatory extracellular ligand-gated ion channel activity
B0005230molecular_functionextracellular ligand-gated ion channel activity
B0042802molecular_functionidentical protein binding
B0005216molecular_functionion channel activity
B0015276molecular_functionligand-gated ion channel activity
B0046872molecular_functionmetal ion binding
B0035091molecular_functionphosphatidylinositol binding
B0051219molecular_functionphosphoprotein binding
B0097603molecular_functiontemperature-gated ion channel activity
B0004888molecular_functiontransmembrane signaling receptor activity
B0048266biological_processbehavioral response to pain
B0098703biological_processcalcium ion import across plasma membrane
B0070588biological_processcalcium ion transmembrane transport
B0006816biological_processcalcium ion transport
B0071468biological_processcellular response to acidic pH
B0071312biological_processcellular response to alkaloid
B0071318biological_processcellular response to ATP
B0071345biological_processcellular response to cytokine stimulus
B0071363biological_processcellular response to growth factor stimulus
B0034605biological_processcellular response to heat
B1990090biological_processcellular response to nerve growth factor stimulus
B0071502biological_processcellular response to temperature stimulus
B0071356biological_processcellular response to tumor necrosis factor
B0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
B0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
B0050960biological_processdetection of temperature stimulus involved in thermoception
B0002024biological_processdiet induced thermogenesis
B0001660biological_processfever generation
B0014047biological_processglutamate secretion
B0006954biological_processinflammatory response
B0034220biological_procession transmembrane transport
B0006629biological_processlipid metabolic process
B0001774biological_processmicroglial cell activation
B0090212biological_processnegative regulation of establishment of blood-brain barrier
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0002790biological_processpeptide secretion
B0043065biological_processpositive regulation of apoptotic process
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0060454biological_processpositive regulation of gastric acid secretion
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0051289biological_processprotein homotetramerization
B1901594biological_processresponse to capsazepine
B0009408biological_processresponse to heat
B0010243biological_processresponse to organonitrogen compound
B0048265biological_processresponse to pain
B0043434biological_processresponse to peptide hormone
B0009268biological_processresponse to pH
B0050954biological_processsensory perception of mechanical stimulus
B0019233biological_processsensory perception of pain
B0060083biological_processsmooth muscle contraction involved in micturition
B0001659biological_processtemperature homeostasis
B0050955biological_processthermoception
B0014832biological_processurinary bladder smooth muscle contraction
D0030054cellular_componentcell junction
D0005829cellular_componentcytosol
D0030425cellular_componentdendrite
D0032591cellular_componentdendritic spine membrane
D0009897cellular_componentexternal side of plasma membrane
D0016021cellular_componentintegral component of membrane
D0005887cellular_componentintegral component of plasma membrane
D0031226cellular_componentintrinsic component of plasma membrane
D0016020cellular_componentmembrane
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0005886cellular_componentplasma membrane
D0045211cellular_componentpostsynaptic membrane
D0045202cellular_componentsynapse
D0005524molecular_functionATP binding
D0005262molecular_functioncalcium channel activity
D0015278molecular_functioncalcium-release channel activity
D0005516molecular_functioncalmodulin binding
D0005261molecular_functioncation channel activity
D0008324molecular_functioncation transmembrane transporter activity
D0017081molecular_functionchloride channel regulator activity
D0005231molecular_functionexcitatory extracellular ligand-gated ion channel activity
D0005230molecular_functionextracellular ligand-gated ion channel activity
D0042802molecular_functionidentical protein binding
D0005216molecular_functionion channel activity
D0015276molecular_functionligand-gated ion channel activity
D0046872molecular_functionmetal ion binding
D0035091molecular_functionphosphatidylinositol binding
D0051219molecular_functionphosphoprotein binding
D0097603molecular_functiontemperature-gated ion channel activity
D0004888molecular_functiontransmembrane signaling receptor activity
D0048266biological_processbehavioral response to pain
D0098703biological_processcalcium ion import across plasma membrane
D0070588biological_processcalcium ion transmembrane transport
D0006816biological_processcalcium ion transport
D0071468biological_processcellular response to acidic pH
D0071312biological_processcellular response to alkaloid
D0071318biological_processcellular response to ATP
D0071345biological_processcellular response to cytokine stimulus
D0071363biological_processcellular response to growth factor stimulus
D0034605biological_processcellular response to heat
D1990090biological_processcellular response to nerve growth factor stimulus
D0071502biological_processcellular response to temperature stimulus
D0071356biological_processcellular response to tumor necrosis factor
D0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
D0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
D0050960biological_processdetection of temperature stimulus involved in thermoception
D0002024biological_processdiet induced thermogenesis
D0001660biological_processfever generation
D0014047biological_processglutamate secretion
D0006954biological_processinflammatory response
D0034220biological_procession transmembrane transport
D0006629biological_processlipid metabolic process
D0001774biological_processmicroglial cell activation
D0090212biological_processnegative regulation of establishment of blood-brain barrier
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0002790biological_processpeptide secretion
D0043065biological_processpositive regulation of apoptotic process
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0060454biological_processpositive regulation of gastric acid secretion
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0051289biological_processprotein homotetramerization
D1901594biological_processresponse to capsazepine
D0009408biological_processresponse to heat
D0010243biological_processresponse to organonitrogen compound
D0048265biological_processresponse to pain
D0043434biological_processresponse to peptide hormone
D0009268biological_processresponse to pH
D0050954biological_processsensory perception of mechanical stimulus
D0019233biological_processsensory perception of pain
D0060083biological_processsmooth muscle contraction involved in micturition
D0001659biological_processtemperature homeostasis
D0050955biological_processthermoception
D0014832biological_processurinary bladder smooth muscle contraction
E0030054cellular_componentcell junction
E0005829cellular_componentcytosol
E0030425cellular_componentdendrite
E0032591cellular_componentdendritic spine membrane
E0009897cellular_componentexternal side of plasma membrane
E0016021cellular_componentintegral component of membrane
E0005887cellular_componentintegral component of plasma membrane
E0031226cellular_componentintrinsic component of plasma membrane
E0016020cellular_componentmembrane
E0043005cellular_componentneuron projection
E0043025cellular_componentneuronal cell body
E0005886cellular_componentplasma membrane
E0045211cellular_componentpostsynaptic membrane
E0045202cellular_componentsynapse
E0005524molecular_functionATP binding
E0005262molecular_functioncalcium channel activity
E0015278molecular_functioncalcium-release channel activity
E0005516molecular_functioncalmodulin binding
E0005261molecular_functioncation channel activity
E0008324molecular_functioncation transmembrane transporter activity
E0017081molecular_functionchloride channel regulator activity
E0005231molecular_functionexcitatory extracellular ligand-gated ion channel activity
E0005230molecular_functionextracellular ligand-gated ion channel activity
E0042802molecular_functionidentical protein binding
E0005216molecular_functionion channel activity
E0015276molecular_functionligand-gated ion channel activity
E0046872molecular_functionmetal ion binding
E0035091molecular_functionphosphatidylinositol binding
E0051219molecular_functionphosphoprotein binding
E0097603molecular_functiontemperature-gated ion channel activity
E0004888molecular_functiontransmembrane signaling receptor activity
E0048266biological_processbehavioral response to pain
E0098703biological_processcalcium ion import across plasma membrane
E0070588biological_processcalcium ion transmembrane transport
E0006816biological_processcalcium ion transport
E0071468biological_processcellular response to acidic pH
E0071312biological_processcellular response to alkaloid
E0071318biological_processcellular response to ATP
E0071345biological_processcellular response to cytokine stimulus
E0071363biological_processcellular response to growth factor stimulus
E0034605biological_processcellular response to heat
E1990090biological_processcellular response to nerve growth factor stimulus
E0071502biological_processcellular response to temperature stimulus
E0071356biological_processcellular response to tumor necrosis factor
E0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
E0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
E0050960biological_processdetection of temperature stimulus involved in thermoception
E0002024biological_processdiet induced thermogenesis
E0001660biological_processfever generation
E0014047biological_processglutamate secretion
E0006954biological_processinflammatory response
E0034220biological_procession transmembrane transport
E0006629biological_processlipid metabolic process
E0001774biological_processmicroglial cell activation
E0090212biological_processnegative regulation of establishment of blood-brain barrier
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0002790biological_processpeptide secretion
E0043065biological_processpositive regulation of apoptotic process
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0060454biological_processpositive regulation of gastric acid secretion
E0045429biological_processpositive regulation of nitric oxide biosynthetic process
E0051289biological_processprotein homotetramerization
E1901594biological_processresponse to capsazepine
E0009408biological_processresponse to heat
E0010243biological_processresponse to organonitrogen compound
E0048265biological_processresponse to pain
E0043434biological_processresponse to peptide hormone
E0009268biological_processresponse to pH
E0050954biological_processsensory perception of mechanical stimulus
E0019233biological_processsensory perception of pain
E0060083biological_processsmooth muscle contraction involved in micturition
E0001659biological_processtemperature homeostasis
E0050955biological_processthermoception
E0014832biological_processurinary bladder smooth muscle contraction
G0030054cellular_componentcell junction
G0005829cellular_componentcytosol
G0030425cellular_componentdendrite
G0032591cellular_componentdendritic spine membrane
G0009897cellular_componentexternal side of plasma membrane
G0016021cellular_componentintegral component of membrane
G0005887cellular_componentintegral component of plasma membrane
G0031226cellular_componentintrinsic component of plasma membrane
G0016020cellular_componentmembrane
G0043005cellular_componentneuron projection
G0043025cellular_componentneuronal cell body
G0005886cellular_componentplasma membrane
G0045211cellular_componentpostsynaptic membrane
G0045202cellular_componentsynapse
G0005524molecular_functionATP binding
G0005262molecular_functioncalcium channel activity
G0015278molecular_functioncalcium-release channel activity
G0005516molecular_functioncalmodulin binding
G0005261molecular_functioncation channel activity
G0008324molecular_functioncation transmembrane transporter activity
G0017081molecular_functionchloride channel regulator activity
G0005231molecular_functionexcitatory extracellular ligand-gated ion channel activity
G0005230molecular_functionextracellular ligand-gated ion channel activity
G0042802molecular_functionidentical protein binding
G0005216molecular_functionion channel activity
G0015276molecular_functionligand-gated ion channel activity
G0046872molecular_functionmetal ion binding
G0035091molecular_functionphosphatidylinositol binding
G0051219molecular_functionphosphoprotein binding
G0097603molecular_functiontemperature-gated ion channel activity
G0004888molecular_functiontransmembrane signaling receptor activity
G0048266biological_processbehavioral response to pain
G0098703biological_processcalcium ion import across plasma membrane
G0070588biological_processcalcium ion transmembrane transport
G0006816biological_processcalcium ion transport
G0071468biological_processcellular response to acidic pH
G0071312biological_processcellular response to alkaloid
G0071318biological_processcellular response to ATP
G0071345biological_processcellular response to cytokine stimulus
G0071363biological_processcellular response to growth factor stimulus
G0034605biological_processcellular response to heat
G1990090biological_processcellular response to nerve growth factor stimulus
G0071502biological_processcellular response to temperature stimulus
G0071356biological_processcellular response to tumor necrosis factor
G0050968biological_processdetection of chemical stimulus involved in sensory perception of pain
G0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
G0050960biological_processdetection of temperature stimulus involved in thermoception
G0002024biological_processdiet induced thermogenesis
G0001660biological_processfever generation
G0014047biological_processglutamate secretion
G0006954biological_processinflammatory response
G0034220biological_procession transmembrane transport
G0006629biological_processlipid metabolic process
G0001774biological_processmicroglial cell activation
G0090212biological_processnegative regulation of establishment of blood-brain barrier
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0002790biological_processpeptide secretion
G0043065biological_processpositive regulation of apoptotic process
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0060454biological_processpositive regulation of gastric acid secretion
G0045429biological_processpositive regulation of nitric oxide biosynthetic process
G0051289biological_processprotein homotetramerization
G1901594biological_processresponse to capsazepine
G0009408biological_processresponse to heat
G0010243biological_processresponse to organonitrogen compound
G0048265biological_processresponse to pain
G0043434biological_processresponse to peptide hormone
G0009268biological_processresponse to pH
G0050954biological_processsensory perception of mechanical stimulus
G0019233biological_processsensory perception of pain
G0060083biological_processsmooth muscle contraction involved in micturition
G0001659biological_processtemperature homeostasis
G0050955biological_processthermoception
G0014832biological_processurinary bladder smooth muscle contraction
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Functional Information from PDB Data

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

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Functional Information from PROSITE/UniProt

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Functional Information from SwissProt/UniProt

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Catalytic Information from CSA

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