5T3M

Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7

Summary for 5T3M

• Entry DOI: 10.2210/pdb5t3m/pdb
• NMR Information: BMRB: 30160
• Descriptor: Mu-theraphotoxin-Hs2a (1 entity in total)
• Functional Keywords: toxin
• Biological source: Haplopelma schmidti (Chinese bird spider)
• Total number of polymer chains: 1
• Total formula weight: 3999.78

Authors

Rahnama, S.,Sharma, G.,Mobli, M. (deposition date: 2016-08-25, release date: 2017-09-06, Last modification date: 2023-06-14)

• Primary citation: Rahnama, S.,Deuis, J.R.,Cardoso, F.C.,Ramanujam, V.,Lewis, R.J.,Rash, L.D.,King, G.F.,Vetter, I.,Mobli, M.; The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.; PLoS ONE, 12:e0173551-e0173551, 2017; PubMed: 28301520; DOI: 10.1371/journal.pone.0173551

Experimental method

SOLUTION NMR