5T3M
Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mu-theraphotoxin-Hs2a | polymer | 35 | 3999.8 | 1 | UniProt (P83303) Pfam (PF07740) | Haplopelma schmidti (Chinese bird spider) | Mu-TRTX-Hs2a,Huwentoxin-4,Huwentoxin-IV,HwTx-IV,Huwentoxin-IVa,HWTX-IVa,Huwentoxin-IVb,HWTX-IVb,Huwentoxin-IVc,HWTX-IVc |
Sequence modifications
A: 1 - 35 (UniProt: P83303)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | Glu 53 | engineered mutation |
| Gly 4 | Glu 56 | engineered mutation |
| Trp 33 | Tyr 85 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 3999.8 | |
| All* | Total formula weight | 3999.8 |
