5T3M

Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS60021
Number of Residues	30
Details	HWTX_1 Huwentoxin-1 family signature. CLgIfkaCnpsndqCCkssklvCsrktRWC

Chain	Residue	Details
A	CYS2-CYS31

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	SITE: Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503

Chain	Residue	Details
A	PHE6
A	ARG26
A	LYS27
A	TRP30
A	LYS32

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Pyrrolidone carboxylic acid (Glu); partial => ECO:0000269|PubMed:23826086

Chain	Residue	Details
A	GLY1

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Isoleucine amide => ECO:0000269|PubMed:12228241

Chain	Residue	Details
A	ILE35

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