2M9L

Solution structure of protoxin-1

Summary for 2M9L

• Entry DOI: 10.2210/pdb2m9l/pdb
• Related: 2M9O
• NMR Information: BMRB: 19300
• Descriptor: Beta-theraphotoxin-Tp1a (1 entity in total)
• Functional Keywords: beta hairpin, toxin
• Biological source: Thrixopelma pruriens (green velvet)
• Cellular location: Secreted: P83480
• Total number of polymer chains: 1
• Total formula weight: 3999.59

Authors

Daly, N. (deposition date: 2013-06-13, release date: 2014-04-30, Last modification date: 2024-10-16)

Primary citation

Gui, J.,Liu, B.,Cao, G.,Lipchik, A.M.,Perez, M.,Dekan, Z.,Mobli, M.,Daly, N.L.,Alewood, P.F.,Parker, L.L.,King, G.F.,Zhou, Y.,Jordt, S.E.,Nitabach, M.N.
A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.
Curr.Biol., 24:473-483, 2014

PubMed Abstract: The venoms of predators have been an excellent source of diverse highly specific peptides targeting ion channels. Here we describe the first known peptide antagonist of the nociceptor ion channel transient receptor potential ankyrin 1 (TRPA1).

PubMed: 24530065
DOI: 10.1016/j.cub.2014.01.013

Experimental method

SOLUTION NMR