7K48

Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV

Summary for 7K48

Entry DOI	10.2210/pdb7k48/pdb
EMDB information	22661
Descriptor	Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a (2 entities in total)
Functional Keywords	ion channel, voltage-gated sodium channel, gating-modifier toxin, membrane protein
Biological source	Escherichia coli (strain K12) More
Total number of polymer chains	8
Total formula weight	290075.36
Authors	Wisedchaisri, G.,Tonggu, L.,Gamal El-Din, T.M.,McCord, E.,Zheng, N.,Catterall, W.A. (deposition date: 2020-09-15, release date: 2020-12-02, Last modification date: 2021-01-20)
Primary citation	Wisedchaisri, G.,Tonggu, L.,Gamal El-Din, T.M.,McCord, E.,Zheng, N.,Catterall, W.A. Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin. Mol.Cell, 81:38-48.e4, 2021 Cited by PubMed: 33232657 DOI: 10.1016/j.molcel.2020.10.039 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation