Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7K48

Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0006811	biological_process	monoatomic ion transport
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
B	0005216	molecular_function	monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0006811	biological_process	monoatomic ion transport
B	0006974	biological_process	DNA damage response
B	0008643	biological_process	carbohydrate transport
B	0015144	molecular_function	carbohydrate transmembrane transporter activity
B	0015768	biological_process	maltose transport
B	0016020	cellular_component	membrane
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0034219	biological_process	carbohydrate transmembrane transport
B	0034289	biological_process	detection of maltose stimulus
B	0042597	cellular_component	periplasmic space
B	0042956	biological_process	maltodextrin transmembrane transport
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B	0055085	biological_process	transmembrane transport
B	0060326	biological_process	cell chemotaxis
B	1901982	molecular_function	maltose binding
B	1990060	cellular_component	maltose transport complex
C	0005216	molecular_function	monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0006811	biological_process	monoatomic ion transport
C	0006974	biological_process	DNA damage response
C	0008643	biological_process	carbohydrate transport
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
D	0005216	molecular_function	monoatomic ion channel activity
D	0005515	molecular_function	protein binding
D	0006811	biological_process	monoatomic ion transport
D	0006974	biological_process	DNA damage response
D	0008643	biological_process	carbohydrate transport
D	0015144	molecular_function	carbohydrate transmembrane transporter activity
D	0015768	biological_process	maltose transport
D	0016020	cellular_component	membrane
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0034219	biological_process	carbohydrate transmembrane transport
D	0034289	biological_process	detection of maltose stimulus
D	0042597	cellular_component	periplasmic space
D	0042956	biological_process	maltodextrin transmembrane transport
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D	0055085	biological_process	transmembrane transport
D	0060326	biological_process	cell chemotaxis
D	1901982	molecular_function	maltose binding
D	1990060	cellular_component	maltose transport complex
E	0005576	cellular_component	extracellular region
E	0008200	molecular_function	ion channel inhibitor activity
F	0005576	cellular_component	extracellular region
F	0008200	molecular_function	ion channel inhibitor activity
G	0005576	cellular_component	extracellular region
G	0008200	molecular_function	ion channel inhibitor activity
H	0005576	cellular_component	extracellular region
H	0008200	molecular_function	ion channel inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO460-ASN477

site_id	PS60021
Number of Residues	30
Details	HWTX_1 Huwentoxin-1 family signature. CLgIfkaCnpsndqCCkssklvCsrktRWC

Chain	Residue	Details
E	CYS2-CYS31

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	SITE: Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305\|PubMed:23760503

Chain	Residue	Details
E	PHE6
F	LYS32
G	PHE6
G	ARG26
G	LYS27
G	TRP30
G	LYS32
H	PHE6
H	ARG26
H	LYS27
H	TRP30
E	ARG26
H	LYS32
E	LYS27
E	TRP30
E	LYS32
F	PHE6
F	ARG26
F	LYS27
F	TRP30

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid (Glu); partial => ECO:0000269\|PubMed:23826086

Chain	Residue	Details
E	GLY1
F	GLY1
G	GLY1
H	GLY1
C	GLU753-ASN763
C	GLU817-GLY818
D	GLU753-ASN763
D	GLU817-GLY818

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Isoleucine amide => ECO:0000269\|PubMed:12228241

Chain	Residue	Details
E	ILE35
F	ILE35
G	ILE35
H	ILE35

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Is directly targeted by the spider protoxin-II => ECO:0000269\|PubMed:30661758

Chain	Residue	Details
A	GLU810
A	ASP815
B	GLU810
B	ASP815
C	GLU810
C	ASP815
D	GLU810
D	ASP815

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)