7K48
Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| A | 0015768 | biological_process | maltose transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0034219 | biological_process | carbohydrate transmembrane transport |
| A | 0034289 | biological_process | detection of maltose stimulus |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042956 | biological_process | maltodextrin transmembrane transport |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 1901982 | molecular_function | maltose binding |
| A | 1990060 | cellular_component | maltose transport complex |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008643 | biological_process | carbohydrate transport |
| B | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| B | 0015768 | biological_process | maltose transport |
| B | 0016020 | cellular_component | membrane |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0034219 | biological_process | carbohydrate transmembrane transport |
| B | 0034289 | biological_process | detection of maltose stimulus |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0042956 | biological_process | maltodextrin transmembrane transport |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0060326 | biological_process | cell chemotaxis |
| B | 1901982 | molecular_function | maltose binding |
| B | 1990060 | cellular_component | maltose transport complex |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006974 | biological_process | DNA damage response |
| C | 0008643 | biological_process | carbohydrate transport |
| C | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| C | 0015768 | biological_process | maltose transport |
| C | 0016020 | cellular_component | membrane |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0034219 | biological_process | carbohydrate transmembrane transport |
| C | 0034289 | biological_process | detection of maltose stimulus |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0042956 | biological_process | maltodextrin transmembrane transport |
| C | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| C | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0060326 | biological_process | cell chemotaxis |
| C | 1901982 | molecular_function | maltose binding |
| C | 1990060 | cellular_component | maltose transport complex |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006974 | biological_process | DNA damage response |
| D | 0008643 | biological_process | carbohydrate transport |
| D | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| D | 0015768 | biological_process | maltose transport |
| D | 0016020 | cellular_component | membrane |
| D | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| D | 0034219 | biological_process | carbohydrate transmembrane transport |
| D | 0034289 | biological_process | detection of maltose stimulus |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0042956 | biological_process | maltodextrin transmembrane transport |
| D | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| D | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0060326 | biological_process | cell chemotaxis |
| D | 1901982 | molecular_function | maltose binding |
| D | 1990060 | cellular_component | maltose transport complex |
Functional Information from PROSITE/UniProt
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| A | PRO460-ASN477 |
| site_id | PS60021 |
| Number of Residues | 30 |
| Details | HWTX_1 Huwentoxin-1 family signature. CLgIfkaCnpsndqCCkssklvCsrktRWC |
| Chain | Residue | Details |
| E | CYS2-CYS31 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI6 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"38381792","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40768348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ITI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 108 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38381792","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40768348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8XMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ITI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 96 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38381792","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40768348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8XMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ITI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"38381792","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40768348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ITI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"38381792","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40768348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ITI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"38381792","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40768348","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ITI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Site: {"description":"Is directly targeted by the spider protoxin-II","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | Site: {"description":"Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A)","evidences":[{"source":"PubMed","id":"23760503","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
