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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7K48

Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0006811biological_processmonoatomic ion transport
A0006974biological_processDNA damage response
A0008643biological_processcarbohydrate transport
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0042597cellular_componentperiplasmic space
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A1901982molecular_functionmaltose binding
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0006811biological_processmonoatomic ion transport
B0006974biological_processDNA damage response
B0008643biological_processcarbohydrate transport
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034219biological_processcarbohydrate transmembrane transport
B0034289biological_processdetection of maltose stimulus
B0042597cellular_componentperiplasmic space
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B1901982molecular_functionmaltose binding
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0006811biological_processmonoatomic ion transport
C0006974biological_processDNA damage response
C0008643biological_processcarbohydrate transport
C0015144molecular_functioncarbohydrate transmembrane transporter activity
C0015768biological_processmaltose transport
C0016020cellular_componentmembrane
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034219biological_processcarbohydrate transmembrane transport
C0034289biological_processdetection of maltose stimulus
C0042597cellular_componentperiplasmic space
C0042956biological_processmaltodextrin transmembrane transport
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C0055085biological_processtransmembrane transport
C0060326biological_processcell chemotaxis
C1901982molecular_functionmaltose binding
D0005216molecular_functionmonoatomic ion channel activity
D0005515molecular_functionprotein binding
D0006811biological_processmonoatomic ion transport
D0006974biological_processDNA damage response
D0008643biological_processcarbohydrate transport
D0015144molecular_functioncarbohydrate transmembrane transporter activity
D0015768biological_processmaltose transport
D0016020cellular_componentmembrane
D0030288cellular_componentouter membrane-bounded periplasmic space
D0034219biological_processcarbohydrate transmembrane transport
D0034289biological_processdetection of maltose stimulus
D0042597cellular_componentperiplasmic space
D0042956biological_processmaltodextrin transmembrane transport
D0043190cellular_componentATP-binding cassette (ABC) transporter complex
D0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D0055085biological_processtransmembrane transport
D0060326biological_processcell chemotaxis
D1901982molecular_functionmaltose binding
E0005576cellular_componentextracellular region
E0008200molecular_functionion channel inhibitor activity
F0005576cellular_componentextracellular region
F0008200molecular_functionion channel inhibitor activity
G0005576cellular_componentextracellular region
G0008200molecular_functionion channel inhibitor activity
H0005576cellular_componentextracellular region
H0008200molecular_functionion channel inhibitor activity
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO460-ASN477
site_idPS60021
Number of Residues30
DetailsHWTX_1 Huwentoxin-1 family signature. CLgIfkaCnpsndqCCkssklvCsrktRWC
ChainResidueDetails
ECYS2-CYS31
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI6
Number of Residues64
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues108
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues96
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues64
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues64
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsSite: {"description":"Is directly targeted by the spider protoxin-II","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues20
DetailsSite: {"description":"Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A)","evidences":[{"source":"PubMed","id":"23760503","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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