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1MKK
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Disulfide deficient mutant of vascular endothelial growth factor A (C61A and C104A)
Descriptor: Vascular Endothelial Growth Factor A
Authors:Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H.
Deposit date:2002-08-29
Release date:2002-12-11
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
6ZBR
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VEGF-A 13:107 crystallized with 4C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Chains: P, PHOSPHATE ION, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-06-09
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
6ZFL
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High resolution structure of VEGF-A 12:107 crystallized in tetragonal form
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Vascular endothelial growth factor A
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-06-17
Release date:2021-06-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
4GLN
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Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n
Descriptor: D-RFX001, Vascular endothelial growth factor A
Authors:Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GLS
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Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21
Descriptor: D- RFX001, D- Vascular endothelial growth factor-A, DI(HYDROXYETHYL)ETHER, ...
Authors:Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
1FLT
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VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Wiesmann, C, De Vos, A.M.
Deposit date:1997-11-20
Release date:1999-01-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
4KZN
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crystal structure of human VEGF-A receptor binding domain
Descriptor: SULFATE ION, TRIETHYLENE GLYCOL, Vascular endothelial growth factor A, ...
Authors:Liaw, Y.C.
Deposit date:2013-05-30
Release date:2014-06-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7114 Å)
Cite:Structural Basis for the Bivalent Glycosylated Human VEGF-A121 and VEGF-A165 in recruiment of Receptor and Co-receptor
to be published
4QAF
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Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)
Descriptor: 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ACETATE ION, Lipocalin-1, ...
Authors:Giese, T, Skerra, A.
Deposit date:2014-05-04
Release date:2015-05-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold
To be Published
6Z13
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VEGF-A 13:107 crystallized with 3C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, AMINO GROUP, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-05-12
Release date:2021-05-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
6ZCD
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VEGF-A 13:107 crystallized with 1C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Derived from V114 peptide, PHOSPHATE ION, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-06-10
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
3QTK
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The crystal structure of chemically synthesized VEGF-A
Descriptor: ACETATE ION, GLYCEROL, Vascular endothelial growth factor A, ...
Authors:Mandal, K, Kent, S.B.H.
Deposit date:2011-02-22
Release date:2011-07-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Total chemical synthesis of biologically active vascular endothelial growth factor.
Angew.Chem.Int.Ed.Engl., 50, 2011
1WQ8
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Crystal structure of Vammin, a VEGF-F from a snake venom
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Vascular endothelial growth factor toxin
Authors:Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
Deposit date:2004-09-23
Release date:2004-12-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
1VPP
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BU of 1vpp by Molmil
COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE
Descriptor: PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
Authors:Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M.
Deposit date:1998-10-09
Release date:1999-02-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
2VPF
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BU of 2vpf by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A, De Vos, A.M.
Deposit date:1997-07-29
Release date:1998-07-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
1WQ9
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BU of 1wq9 by Molmil
Crystal structure of VR-1, a VEGF-F from a snake venom
Descriptor: Vascular endothelial growth factor
Authors:Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
Deposit date:2004-09-24
Release date:2004-12-07
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
1FZV
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BU of 1fzv by Molmil
THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PLACENTA GROWTH FACTOR
Authors:Iyer, S, Leonidas, D.D, Swaminathan, G.J, Maglione, D, Battisti, M, Tucci, M, Persico, M.G, Acharya, K.R.
Deposit date:2000-10-04
Release date:2001-05-09
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
J.Biol.Chem., 276, 2001
5HHD
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BU of 5hhd by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21
Descriptor: D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ...
Authors:Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
6Z3F
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BU of 6z3f by Molmil
VEGF-A 13:107 crystallized with 2C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, AMINO GROUP, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-05-20
Release date:2021-06-02
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
5HHC
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BU of 5hhc by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n
Descriptor: D- Vascular endothelial growth factor-A, GLYCEROL, Vascular endothelial growth factor A
Authors:Uppalapati, M, Lee, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
1MJV
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BU of 1mjv by Molmil
DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A and C60A)
Descriptor: Vascular Endothelial Growth Factor A
Authors:Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H.
Deposit date:2002-08-28
Release date:2002-12-11
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
5O4E
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BU of 5o4e by Molmil
Crystal structure of VEGF in complex with heterodimeric Fcab JanusCT6
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Mlynek, G, Lobner, E, Kubinger, K, Humm, A, Obinger, C, Djinovic-Carugo, K.
Deposit date:2017-05-29
Release date:2017-08-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex.
MAbs, 9, 2017
4HQU
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BU of 4hqu by Molmil
Crystal structure of human PDGF-BB in complex with a modified nucleotide aptamer (SOMAmer SL5)
Descriptor: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
Authors:Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQX
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CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)
Descriptor: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
Authors:Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
4QCI
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PDGF-B blocking antibody bound to PDGF-BB
Descriptor: Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain
Authors:Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G.
Deposit date:2014-05-12
Release date:2015-03-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
3MJG
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The structure of a platelet derived growth factor receptor complex
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-type platelet-derived growth factor receptor, ...
Authors:Shim, A.H.R, He, X.
Deposit date:2010-04-12
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Proc.Natl.Acad.Sci.USA, 107, 2010

 

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