4GLS
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21
Summary for 4GLS
Entry DOI | 10.2210/pdb4gls/pdb |
Related | 3QTK 4GLN 4GLU |
Descriptor | D- Vascular endothelial growth factor-A, L- RFX001, D- RFX001, ... (7 entities in total) |
Functional Keywords | heterochiral protein-protein complex, d-protein antagonist, growth factor-inhibitor complex, growth factor/inhibitor |
Cellular location | Secreted: P15692 |
Total number of polymer chains | 8 |
Total formula weight | 73492.41 |
Authors | Mandal, K.,Uppalapati, M.,Ault-Riche, D.,Kenney, J.,Lowitz, J.,Sidhu, S.,Kent, S.B.H. (deposition date: 2012-08-14, release date: 2012-09-05, Last modification date: 2023-12-06) |
Primary citation | Mandal, K.,Uppalapati, M.,Ault-Riche, D.,Kenney, J.,Lowitz, J.,Sidhu, S.S.,Kent, S.B. Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc.Natl.Acad.Sci.USA, 109:14779-14784, 2012 Cited by PubMed: 22927390DOI: 10.1073/pnas.1210483109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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