4QAF

Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)

Summary for 4QAF

• Entry DOI: 10.2210/pdb4qaf/pdb
• Descriptor: Lipocalin-1, Vascular endothelial growth factor A, 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ... (6 entities in total)
• Functional Keywords: beta-barrel, binding protein, engineered lipocalin, transport protein-signaling protein complex, transport protein/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P31025 P15692
• Total number of polymer chains: 4
• Total formula weight: 59602.76

Authors

Giese, T.,Skerra, A. (deposition date: 2014-05-04, release date: 2015-05-06, Last modification date: 2023-09-20)

• Primary citation: Giese, T.,Skerra, A.; Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)