5HHD
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21
Summary for 5HHD
Entry DOI | 10.2210/pdb5hhd/pdb |
Related | 4GLS |
Descriptor | Vascular endothelial growth factor A, D-Peptide RFX037.D, D-Vascular endothelial growth factor, ... (7 entities in total) |
Functional Keywords | heterochiral protein-protein complex, d-protein antagonist, growth factor-inhibitor complex, racemic crystallography, de novo protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 79497.07 |
Authors | Uppalapati, M.,LEE, D.J.,Mandal, K.,Kent, S.B.H.,Sidhu, S. (deposition date: 2016-01-10, release date: 2016-03-09, Last modification date: 2023-11-15) |
Primary citation | Uppalapati, M.,Lee, D.J.,Mandal, K.,Li, H.,Miranda, L.P.,Lowitz, J.,Kenney, J.,Adams, J.J.,Ault-Riche, D.,Kent, S.B.,Sidhu, S.S. A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11:1058-1065, 2016 Cited by PubMed: 26745345DOI: 10.1021/acschembio.5b01006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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