4QCI
PDGF-B blocking antibody bound to PDGF-BB
Summary for 4QCI
Entry DOI | 10.2210/pdb4qci/pdb |
Descriptor | anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain, Platelet-derived growth factor subunit B, ... (4 entities in total) |
Functional Keywords | growth factor cytokine fold, growth factor hormone, pdgfr-beta receptor, extracellular, cytokine-cytokine receptor complex, cytokine/cytokine receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01127 |
Total number of polymer chains | 6 |
Total formula weight | 117415.94 |
Authors | Kuai, J.,Mosyak, L.,Tam, M.,LaVallie, E.,Pullen, N.,Carven, G. (deposition date: 2014-05-12, release date: 2015-03-11, Last modification date: 2024-03-06) |
Primary citation | Kuai, J.,Mosyak, L.,Brooks, J.,Cain, M.,Carven, G.J.,Ogawa, S.,Ishino, T.,Tam, M.,Lavallie, E.R.,Yang, Z.,Ponsel, D.,Rauchenberger, R.,Arch, R.,Pullen, N. Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta. Biochemistry, 54:1918-1929, 2015 Cited by PubMed: 25707433DOI: 10.1021/bi5015425 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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