3QTK

The crystal structure of chemically synthesized VEGF-A

Summary for 3QTK

Entry DOI	10.2210/pdb3qtk/pdb
Descriptor	Vascular endothelial growth factor A, ACETATE ION, trifluoroacetic acid, ... (5 entities in total)
Functional Keywords	covalent dimer, cysteine knot protein, growth factor, x-ray crystal structure, human vegf-a, hormone
Biological source	Homo sapiens (human)
Cellular location	Secreted: P15692
Total number of polymer chains	6
Total formula weight	73216.95
Authors	Mandal, K.,Kent, S.B.H. (deposition date: 2011-02-22, release date: 2011-07-27, Last modification date: 2024-10-16)
Primary citation	Mandal, K.,Kent, S.B. Total chemical synthesis of biologically active vascular endothelial growth factor. Angew.Chem.Int.Ed.Engl., 50:8029-8033, 2011 Cited by PubMed Abstract: Efficient access: the 204-residue covalent-dimer vascular endothelial growth factor with full mitogenic activity was prepared from three unprotected peptide segments by one-pot native chemical ligations. The covalent structure of the synthetic VEGF was confirmed by precise mass measurement, and the three-dimensional structure of the synthetic protein was determined by high-resolution X-ray crystallography. PubMed: 21744452 DOI: 10.1002/anie.201103237 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.849 Å)

Structure validation