5O4E

Crystal structure of VEGF in complex with heterodimeric Fcab JanusCT6

Summary for 5O4E

• Entry DOI: 10.2210/pdb5o4e/pdb
• Related: 5K64 5K65
• Descriptor: Immunoglobulin gamma-1 heavy chain, CACODYLATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (12 entities in total)
• Functional Keywords: antibody engineering, immunoglobulin g1, fc fragment, fcab, heterodimeric fcab, ch3 domain, vegf, vascular endothelial growth factor, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 130697.28

Authors

Mlynek, G.,Lobner, E.,Kubinger, K.,Humm, A.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2017-05-29, release date: 2017-08-30, Last modification date: 2020-07-29)

• Primary citation: Lobner, E.,Humm, A.S.,Mlynek, G.,Kubinger, K.,Kitzmuller, M.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.; Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex.; MAbs, 9:1088-1104, 2017; PubMed: 28816592; DOI: 10.1080/19420862.2017.1364825

Experimental method

X-RAY DIFFRACTION (2.15 Å)