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5K64

Crystal structure of VEGF binding IgG1-Fc (Fcab 448)

Summary for 5K64
Entry DOI10.2210/pdb5k64/pdb
DescriptorIg gamma-1 chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywordsimmune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, vegf, vascular endothelial growth factor
Biological sourceHomo sapiens (Human)
Cellular locationSecreted : P01857
Total number of polymer chains2
Total formula weight53943.01
Authors
Humm, A.,Lobner, E.,Kitzmuller, M.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (deposition date: 2016-05-24, release date: 2017-09-06, Last modification date: 2024-01-10)
Primary citationLobner, E.,Humm, A.S.,Mlynek, G.,Kubinger, K.,Kitzmuller, M.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C.
Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex.
MAbs, 9:1088-1104, 2017
Cited by
PubMed: 28816592
DOI: 10.1080/19420862.2017.1364825
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.44 Å)
Structure validation

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