5O4E
Crystal structure of VEGF in complex with heterodimeric Fcab JanusCT6
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Immunoglobulin gamma-1 heavy chain | polymer | 223 | 25176.6 | 1 | UniProt (P0DOX5) Pfam (PF07654) In PDB | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
2 | B, D | Immunoglobulin gamma-1 heavy chain | polymer | 228 | 25916.5 | 2 | UniProt (P0DOX5) Pfam (PF07654) In PDB | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
3 | C | Immunoglobulin gamma-1 heavy chain | polymer | 222 | 25047.4 | 1 | UniProt (P0DOX5) Pfam (PF07654) In PDB | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
4 | E, F | Vascular endothelial growth factor A | polymer | 96 | 11260.1 | 2 | UniProt (P15692) Pfam (PF00341) In PDB | Homo sapiens (Human) | VEGF-A,Vascular permeability factor,VPF |
5 | G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 2 | In PDB GlyTouCan (G80858MF) | |||
6 | I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G85856KC) | |||
7 | J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB GlyTouCan (G64481DJ) | |||
8 | A, C, D, E, F | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 10 | Chemie (MPD) | |||
9 | A | (4R)-2-METHYLPENTANE-2,4-DIOL | non-polymer | 118.2 | 1 | Chemie (MRD) | |||
10 | A, E | CACODYLATE ION | non-polymer | 137.0 | 2 | Chemie (CAC) | |||
11 | D | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
12 | water | water | 18.0 | 242 | Chemie (HOH) |
Sequence modifications
A: 225 - 447 (UniProt: P0DOX5)
B, D: 225 - 447 (UniProt: P0DOX5)
C: 225 - 446 (UniProt: P0DOX5)
E, F: 13 - 108 (UniProt: P15692)
PDB | External Database | Details |
---|---|---|
Val 350 | Thr 352 | engineered mutation |
Leu 366 | Thr 368 | engineered mutation |
Leu 392 | Lys 394 | engineered mutation |
Trp 394 | Thr 396 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Val 350 | Thr 352 | engineered mutation |
Tyr 351 | Leu 353 | engineered mutation |
Arg 359 | Thr 361 | engineered mutation |
Phe 360 | Lys 362 | engineered mutation |
Tyr 361 | Asn 363 | engineered mutation |
Asp 388 | - | insertion |
Ile 389 | - | insertion |
Phe 389 | - | insertion |
Pro 389 | - | insertion |
Asn 389 | - | insertion |
Gly 389 | Glu 390 | engineered mutation |
Leu 389 | Asn 391 | engineered mutation |
Ala 405 | Phe 407 | engineered mutation |
Val 407 | Tyr 409 | engineered mutation |
Pro 413 | Asp 415 | engineered mutation |
Tyr 414 | Lys 416 | engineered mutation |
Pro 415 | Ser 417 | engineered mutation |
Ser 416 | Arg 418 | engineered mutation |
Leu 418 | Gln 420 | engineered mutation |
Met 419 | Gln 421 | engineered mutation |
Thr 421 | Asn 423 | engineered mutation |
Arg 422 | Val 424 | engineered mutation |
His 440 | Ser 442 | engineered mutation |
Glu 442 | Ser 444 | engineered mutation |
Tyr 443 | Leu 445 | engineered mutation |
Gln 444 | Ser 446 | engineered mutation |
Trp 445 | Pro 447 | engineered mutation |
Pro 446 | Gly 448 | engineered mutation |
Thr 447 | Lys 449 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Val 350 | Thr 352 | engineered mutation |
Leu 366 | Thr 368 | engineered mutation |
Leu 392 | Lys 394 | engineered mutation |
Trp 394 | Thr 396 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 13 | Glu 39 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 124577.2 | |
Branched | Number of molecules | 4 |
Total formula weight | 4424.1 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 1696.0 | |
All* | Total formula weight | 130697.3 |