Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7LL9
DownloadVisualize
BU of 7ll9 by Molmil
D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A
Descriptor: Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V2
Authors:Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S.
Deposit date:2021-02-03
Release date:2021-03-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
Acs Chem.Biol., 16, 2021
7LL8
DownloadVisualize
BU of 7ll8 by Molmil
D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A
Descriptor: Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V1
Authors:Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S.
Deposit date:2021-02-03
Release date:2021-02-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
Acs Chem.Biol., 16, 2021
7KF1
DownloadVisualize
BU of 7kf1 by Molmil
Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF
Descriptor: CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, anti-VEGF-A Fab bH1 heavy chain, ...
Authors:Shi, R, Picard, M.-E, Manenda, M.S.
Deposit date:2020-10-13
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF
to be published
7KF0
DownloadVisualize
BU of 7kf0 by Molmil
Crystal structure of bH1 Fab variant (CDR H3 loop design 13_0346) in complex with VEGF
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, ...
Authors:Shi, R, Picard, M.-E.
Deposit date:2020-10-13
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF
to be published
7KEZ
DownloadVisualize
BU of 7kez by Molmil
Crystal structure of bH1 Fab variant (CDR H3 loop design 16_0325) in complex with VEGF
Descriptor: CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, anti-VEGF-A Fab bH1 heavy chain, ...
Authors:Shi, R, Manenda, M.S, Picard, M.-E.
Deposit date:2020-10-13
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF
to be published
6ZFL
DownloadVisualize
BU of 6zfl by Molmil
High resolution structure of VEGF-A 12:107 crystallized in tetragonal form
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Vascular endothelial growth factor A
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-06-17
Release date:2021-06-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
6ZCD
DownloadVisualize
BU of 6zcd by Molmil
VEGF-A 13:107 crystallized with 1C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Derived from V114 peptide, PHOSPHATE ION, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-06-10
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
6ZBR
DownloadVisualize
BU of 6zbr by Molmil
VEGF-A 13:107 crystallized with 4C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Chains: P, PHOSPHATE ION, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-06-09
Release date:2021-06-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
6Z3F
DownloadVisualize
BU of 6z3f by Molmil
VEGF-A 13:107 crystallized with 2C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, AMINO GROUP, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-05-20
Release date:2021-06-02
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
6Z13
DownloadVisualize
BU of 6z13 by Molmil
VEGF-A 13:107 crystallized with 3C bicyclic peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, AMINO GROUP, ...
Authors:Gaucher, J.-F, Broussy, S, Reille-Seroussi, M.
Deposit date:2020-05-12
Release date:2021-05-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.
Chemistry, 2022
6V7K
DownloadVisualize
BU of 6v7k by Molmil
Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with one copy of HH4, an alpha/beta-Peptide with Irregular Secondary Structure
Descriptor: Vascular endothelial growth factor A, alpha/beta-Peptide HH4
Authors:Thomas, N.C, Forest, K.T, Gellman, S.H.
Deposit date:2019-12-08
Release date:2020-12-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High-Resolution Structure for a Complex Between One Copy of a Non-Helical Foldamer and VEGF
to be published
6T9E
DownloadVisualize
BU of 6t9e by Molmil
Crystal structure of a bispecific DutaFab in complex with human PDGF
Descriptor: DutaFab mat VH chain, DutaFab mat VL chain, Platelet-derived growth factor subunit B
Authors:Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H.
Deposit date:2019-10-28
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.
Nat Commun, 12, 2021
6T9D
DownloadVisualize
BU of 6t9d by Molmil
Crystal structure of a bispecific DutaFab in complex with human VEGF121
Descriptor: VP mat DutaFab VH chain, VP mat DutaFab VL chain, Vascular endothelial growth factor A
Authors:Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H.
Deposit date:2019-10-28
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.
Nat Commun, 12, 2021
6D3O
DownloadVisualize
BU of 6d3o by Molmil
Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with HH4, an alpha/beta-Peptide with Irregular Secondary Structure
Descriptor: HH4 alpha/beta-Peptide, Vascular endothelial growth factor A
Authors:Thomas, N.C, Forest, K.T, Gellman, S.H.
Deposit date:2018-04-16
Release date:2019-04-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:High-Resolution Structures for a Complex Between a Non-Helical Foldamer and VEGF
To Be Published
6BFT
DownloadVisualize
BU of 6bft by Molmil
Structure of Bevacizumab Fab mutant in complex with VEGF
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Avastin Heavy Chain Fab fragment mutant, Avastin Light Chain Fab fragment mutant, ...
Authors:Christie, M, Christ, D.
Deposit date:2017-10-27
Release date:2018-10-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Stable human IgG antibody therapeutics with native framework structure
To Be Published
5T89
DownloadVisualize
BU of 5t89 by Molmil
Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vascular endothelial growth factor A, ...
Authors:Markovic-Mueller, S, Stuttfeld, E, Asthana, M, Weinert, T, Bliven, S, Goldie, K.N, Kisko, K, Capitani, G, Ballmer-Hofer, K.
Deposit date:2016-09-07
Release date:2017-02-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A.
Structure, 25, 2017
5O4E
DownloadVisualize
BU of 5o4e by Molmil
Crystal structure of VEGF in complex with heterodimeric Fcab JanusCT6
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Mlynek, G, Lobner, E, Kubinger, K, Humm, A, Obinger, C, Djinovic-Carugo, K.
Deposit date:2017-05-29
Release date:2017-08-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex.
MAbs, 9, 2017
5HHD
DownloadVisualize
BU of 5hhd by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21
Descriptor: D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ...
Authors:Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
5HHC
DownloadVisualize
BU of 5hhc by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n
Descriptor: D- Vascular endothelial growth factor-A, GLYCEROL, Vascular endothelial growth factor A
Authors:Uppalapati, M, Lee, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
5FV2
DownloadVisualize
BU of 5fv2 by Molmil
Crystal structure of hVEGF in complex with VH domain antibody
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR, VH DOMAIN ANTIBODY
Authors:Chung, C, Batuwangala, T.
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
5FV1
DownloadVisualize
BU of 5fv1 by Molmil
Crystal structure of hVEGF in complex with VK domain antibody
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR A, VK DOMAIN ANTIBODY
Authors:Chung, C, Walker, A.
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
4ZFF
DownloadVisualize
BU of 4zff by Molmil
Dual-acting Fab 5A12 in complex with VEGF
Descriptor: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ...
Authors:Harris, S.F, Wu, P.
Deposit date:2015-04-21
Release date:2015-07-01
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
4WPB
DownloadVisualize
BU of 4wpb by Molmil
Vascular endothelial growth factor in complex with alpha/beta-VEGF-1
Descriptor: Vascular endothelial growth factor A, alpha/beta-VEGF-1
Authors:Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T.
Deposit date:2014-10-17
Release date:2015-04-15
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold.
Proc.Natl.Acad.Sci.USA, 112, 2015
4QCI
DownloadVisualize
BU of 4qci by Molmil
PDGF-B blocking antibody bound to PDGF-BB
Descriptor: Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain
Authors:Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G.
Deposit date:2014-05-12
Release date:2015-03-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
4QAF
DownloadVisualize
BU of 4qaf by Molmil
Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)
Descriptor: 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ACETATE ION, Lipocalin-1, ...
Authors:Giese, T, Skerra, A.
Deposit date:2014-05-04
Release date:2015-05-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold
To be Published

 

123>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon