4ZFF

Dual-acting Fab 5A12 in complex with VEGF

Summary for 4ZFF

• Entry DOI: 10.2210/pdb4zff/pdb
• Related: 4ZFG
• Descriptor: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, Vascular endothelial growth factor A, ... (5 entities in total)
• Functional Keywords: fab, daf, angiogenesis, tie receptor, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : P15692
• Total number of polymer chains: 6
• Total formula weight: 118451.12

Authors

Harris, S.F.,Wu, P. (deposition date: 2015-04-21, release date: 2015-07-01, Last modification date: 2015-09-16)

• Primary citation: Koenig, P.,Lee, C.V.,Sanowar, S.,Wu, P.,Stinson, J.,Harris, S.F.,Fuh, G.; Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.; J.Biol.Chem., 290:21773-21786, 2015; PubMed: 26088137; DOI: 10.1074/jbc.M115.662783

Experimental method

X-RAY DIFFRACTION (2.75 Å)