5FV2

Crystal structure of hVEGF in complex with VH domain antibody

Summary for 5FV2

• Entry DOI: 10.2210/pdb5fv2/pdb
• Related: 5FV1
• Descriptor: VH DOMAIN ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR (2 entities in total)
• Functional Keywords: hormone, growth factor receptor, vegf, domain antibody, vascular endothelial growth factor
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 6
• Total formula weight: 78881.45

Authors

Chung, C.,Batuwangala, T. (deposition date: 2016-02-02, release date: 2016-02-17, Last modification date: 2019-05-15)

• Primary citation: Walker, A.,Chung, C.,Neu, M.,Burman, M.,Batuwangala, T.,Jones, G.,Tang, C.,Steward, M.,Mullin, M.,Tournier, N.,Lewis, A.,Korczynska, J.,Chung, V.,Catchpole, I.; Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.; J.Biol.Chem., 291:5500-, 2016; PubMed: 26728464; DOI: 10.1074/JBC.M115.691162

Experimental method

X-RAY DIFFRACTION (3.45 Å)