7KF1

Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF

Summary for 7KF1

• Entry DOI: 10.2210/pdb7kf1/pdb
• Descriptor: anti-VEGF-A Fab bH1 heavy chain, anti-VEGF-A Fab bH1 light chain, Isoform L-VEGF206 of Vascular endothelial growth factor A, ... (5 entities in total)
• Functional Keywords: fab-antigen complex, cdr h3 loop, vegf, antibody design, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 252035.39

Authors

Shi, R.,Picard, M.-E.,Manenda, M.S. (deposition date: 2020-10-13, release date: 2021-11-10, Last modification date: 2023-10-18)

• Primary citation: Picard, M.-E.,Manenda, M.S.,Corbeil, C.,Sulea, T.,Baardsness, J.,Hogues, H.,Gaudreault, F.,Deprez, C.,Purisima, E.O.,Shi, R.; Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF; to be published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)