7KF1

Crystal structure of bH1 Fab variant (CDR H3 loop design 14_0130) in complex with VEGF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (H, A, D, G)	anti-VEGF-A Fab bH1 heavy chain	polymer	237	25397.5	4		Homo sapiens
2	B, E, H, K (L, B, E, I)	anti-VEGF-A Fab bH1 light chain	polymer	218	23956.6	4		Homo sapiens
3	C, F, I, L (V, C, F, J)	Isoform L-VEGF206 of Vascular endothelial growth factor A	polymer	116	13548.4	4	UniProt (P15692-14) Pfam (PF00341) UniProt (by SIFTS) (P15692)	Homo sapiens (Human)	VEGF-A,Vascular permeability factor,VPF
4	M, N, O, P, Q... (H, L, A, D, G)	CHLORIDE ION	non-polymer		35.5	12	Chemie (CL)
5	AA, BA, CA, DA, EA... (V, A, B, C, D...)	water	water		18.0	811	Chemie (HOH)

Sequence modifications

V, C, F, J: 1 - 110 (UniProt: P15692-14)

PDB	External Database	Details
His 111	-	expression tag
His 112	-	expression tag
His 113	-	expression tag
His 114	-	expression tag
His 115	-	expression tag
His 116	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	251610.0
Non-Polymers*	Number of molecules	12
	Total formula weight	425.4
All*	Total formula weight	252035.4

*Water molecules are not included.