Author results

1CS4
  • Download 1cs4
  • View 1cs4
Molmil generated image of 1cs4
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
分子名称:TYPE V ADENYLATE CYCLASE, TYPE II ADENYLATE CYCLASE, GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ...
著者Tesmer, J.J.G., Dessauer, C.A., Sunahara, R.K., Johnson, R.A., Gilman, A.G., Sprang, S.R.
登録日1999-08-16
公開日2001-01-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
1CUL
  • Download 1cul
  • View 1cul
Molmil generated image of 1cul
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG
分子名称:TYPE V ADENYLYL CYCLASE, TYPE II ADENYLYL CYCLASE, GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ...
著者Tesmer, J.J.G., Dessauer, C.A., Sunahara, R.K., Johnson, R.A., Gilman, A.G., Sprang, S.R.
登録日1999-08-20
公開日2001-01-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
3P0G
  • Download 3p0g
  • View 3p0g
Molmil generated image of 3p0g
STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE BETA2 ADRENOCEPTOR
分子名称:Beta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, ...
著者Rasmussen, S.G.F., Choi, H.-J., Fung, J.J., Pardon, E., Casarosa, P., Chae, P.S., DeVree, B.T., Rosenbaum, D.M., Thian, F.S., Kobilka, T.S., Schnapp, A., Konetzki, I., Sunahara, R.K., Gellman, S.H., Pautsch, A., Steyaert, J., Weis, W.I., Kobilka, B.K.
登録日2010-09-28
公開日2011-01-19
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Nature, 469, 2011
3PDS
  • Download 3pds
  • View 3pds
Molmil generated image of 3pds
IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX
分子名称:Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ...
著者Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.
登録日2010-10-24
公開日2011-01-12
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
3SN6
  • Download 3sn6
  • View 3sn6
Molmil generated image of 3sn6
CRYSTAL STRUCTURE OF THE BETA2 ADRENERGIC RECEPTOR-GS PROTEIN COMPLEX
分子名称:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Rasmussen, S.G.F., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., Thian, F.S., Chae, P.S., Pardon, E., Calinski, D., Mathiesen, J.M., Shah, S.T.A., Lyons, J.A., Caffrey, M., Gellman, S.H., Steyaert, J., Skiniotis, G., Weis, W.I., Sunahara, R.K., Kobilka, B.K.
登録日2011-06-28
公開日2011-07-20
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
4DKL
  • Download 4dkl
  • View 4dkl
Molmil generated image of 4dkl
CRYSTAL STRUCTURE OF THE MU-OPIOID RECEPTOR BOUND TO A MORPHINAN ANTAGONIST
分子名称:Mu-type opioid receptor, lysozyme chimera, methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate, ...
著者Manglik, A., Kruse, A.C., Kobilka, T.S., Thian, F.S., Mathiesen, J.M., Sunahara, R.K., Pardo, L., Weis, W.I., Kobilka, B.K., Granier, S.
登録日2012-02-03
公開日2012-03-21
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist.
Nature, 485, 2012
5ZHP
  • Download 5zhp
  • View 5zhp
Molmil generated image of 5zhp
M3 MUSCARINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH A SELECTIVE ANTAGONIST
分子名称:Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, TETRAETHYLENE GLYCOL, MALTOSE, ...
著者Liu, H., Hofmann, J., Fish, I., Schaake, B., Eitel, K., Bartuschat, A., Kaindl, J., Rampp, H., Banerjee, A., Hubner, H., Clark, M.J., Vincent, S.G., Fisher, J., Heinrich, M., Hirata, K., Liu, X., Sunahara, R.K., Shoichet, B.K., Kobilka, B.K., Gmeiner, P.
登録日2018-03-13
公開日2018-11-28
最終更新日2018-12-05
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MXT
  • Download 6mxt
  • View 6mxt
Molmil generated image of 6mxt
CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
分子名称:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
著者Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
登録日2018-10-31
公開日2018-11-14
実験手法X-RAY DIFFRACTION (2.959342 Å)
主引用文献Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
1AZT
  • Download 1azt
  • View 1azt
Molmil generated image of 1azt
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
分子名称:GS-ALPHA, MAGNESIUM ION, PHOSPHATE ION, ...
著者Tesmer, J.J.G., Sprang, S.R.
登録日1997-11-20
公開日1998-02-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
1CJK
  • Download 1cjk
  • View 1cjk
Molmil generated image of 1cjk
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN
分子名称:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
著者Tesmer, J.J.G., Sprang, S.R.
登録日1999-04-16
公開日1999-08-31
最終更新日2011-09-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJT
  • Download 1cjt
  • View 1cjt
Molmil generated image of 1cjt
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG
分子名称:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
著者Tesmer, J.J.G., Sprang, S.R.
登録日1999-04-16
公開日1999-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJU
  • Download 1cju
  • View 1cju
Molmil generated image of 1cju
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG
分子名称:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
著者Tesmer, J.J.G., Sprang, S.R.
登録日1999-04-16
公開日1999-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJV
  • Download 1cjv
  • View 1cjv
Molmil generated image of 1cjv
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN
分子名称:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
著者Tesmer, J.J.G., Sprang, S.R.
登録日1999-04-19
公開日1999-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1AZS
  • Download 1azs
  • View 1azs
Molmil generated image of 1azs
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE
分子名称:VC1, IIC2, GS-ALPHA, ...
著者Tesmer, J.J.G., Sprang, S.R.
登録日1997-11-20
公開日1998-02-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Science, 278, 1997
3I2F
  • Download 3i2f
  • View 3i2f
Molmil generated image of 3i2f
COCAINE ESTERASE WITH MUTATIONS T172R / G173Q, BOUND TO DTT ADDUCT
分子名称:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
著者Tesmer, J.J.G., Nance, M.R.
登録日2009-06-29
公開日2010-06-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2G
  • Download 3i2g
  • View 3i2g
Molmil generated image of 3i2g
COCAINE ESTERASE WITH MUTATION G173Q, BOUND TO DTT ADDUCT
分子名称:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
著者Tesmer, J.J.G., Nance, M.R.
登録日2009-06-29
公開日2010-06-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2H
  • Download 3i2h
  • View 3i2h
Molmil generated image of 3i2h
COCAINE ESTERASE WITH MUTATION L169K, BOUND TO DTT ADDUCT
分子名称:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
著者Tesmer, J.J.G., Nance, M.R.
登録日2009-06-29
公開日2010-06-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2I
  • Download 3i2i
  • View 3i2i
Molmil generated image of 3i2i
COCAINE ESTERASE WITH MUTATION T172R, BOUND TO DTT ADDUCT
分子名称:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
著者Tesmer, J.J.G., Nance, M.R.
登録日2009-06-29
公開日2010-06-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2J
  • Download 3i2j
  • View 3i2j
Molmil generated image of 3i2j
COCAINE ESTERASE, WILD TYPE, WITHOUT A LIGAND
分子名称:Cocaine esterase, CHLORIDE ION, GLYCEROL, ...
著者Tesmer, J.J.G., Nance, M.R.
登録日2009-06-29
公開日2010-06-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2K
  • Download 3i2k
  • View 3i2k
Molmil generated image of 3i2k
COCAINE ESTERASE, WILD TYPE, BOUND TO A DTT ADDUCT
分子名称:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
著者Tesmer, J.J.G., Nance, M.R.
登録日2009-06-29
公開日2010-06-16
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3IDA
  • Download 3ida
  • View 3ida
Molmil generated image of 3ida
THERMOSTABLE COCAINE ESTERASE WITH MUTATIONS L169K AND G173Q, BOUND TO DTT ADDUCT
分子名称:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
著者Tesmer, J.J.G., Nance, M.R.
登録日2009-07-20
公開日2010-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse.
Mol.Pharmacol., 77, 2010
3PUH
  • Download 3puh
  • View 3puh
Molmil generated image of 3puh
COCAINE ESTERASE, WILD-TYPE BIOLOGICALLY ACTIVE DIMER
分子名称:Cocaine esterase, GLYCEROL, SULFATE ION
著者Nance, M.R., Tesmer, J.J.G.
登録日2010-12-04
公開日2011-09-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3PUI
  • Download 3pui
  • View 3pui
Molmil generated image of 3pui
COCAINE ESTERASE WITH MUTATIONS G4C, S10C
分子名称:Cocaine esterase, CHLORIDE ION, SODIUM ION
著者Nance, M.R., Tesmer, J.J.G.
登録日2010-12-04
公開日2011-09-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011