7XKA
Structure of human beta2 adrenergic receptor bound to constrained epinephrine
Summary for 7XKA
Entry DOI | 10.2210/pdb7xka/pdb |
Descriptor | Endolysin,Beta-2 adrenergic receptor, Camelid Antibody Fragment, (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, ... (5 entities in total) |
Functional Keywords | gpcr, membrane protein |
Biological source | Enterobacteria phage T4 (Bacteriophage T4) More |
Total number of polymer chains | 2 |
Total formula weight | 66652.65 |
Authors | Xu, X.,Shonberg, J.,Kaindl, J.,Clark, M.,Stobel, A.,Maul, L.,Mayer, D.,Hubner, H.,Venkatakrishnan, A.,Dror, R.,Kobilka, B.K.,Sunahara, R.,Liu, X.,Gmeiner, P. (deposition date: 2022-04-19, release date: 2023-04-26, Last modification date: 2023-11-29) |
Primary citation | Xu, X.,Shonberg, J.,Kaindl, J.,Clark, M.J.,Stossel, A.,Maul, L.,Mayer, D.,Hubner, H.,Hirata, K.,Venkatakrishnan, A.J.,Dror, R.O.,Kobilka, B.K.,Sunahara, R.K.,Liu, X.,Gmeiner, P. Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics. Nat Commun, 14:2138-2138, 2023 Cited by PubMed: 37059717DOI: 10.1038/s41467-023-37808-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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