3PUH

Cocaine Esterase, wild-type biologically active dimer

Summary for 3PUH

Related3i2f 3i2g 3i2h 3i2i 3i2j 1ju3 3ida 1ju4 3PUI
DescriptorCocaine esterase, GLYCEROL, SULFATE ION, ... (4 entities in total)
Functional Keywordsalpha/beta hydrolase, jelly-roll beta-barrel, cleavage of cocaine, hydrolase
Biological sourceRhodococcus sp.
Cellular locationCytoplasm  Q9L9D7
Total number of polymer chains2
Total molecular weight128080.72
Authors
Nance, M.R.,Tesmer, J.J.G. (deposition date: 2010-12-04, release date: 2011-09-21, Last modification date: 2017-11-08)
Primary citation
Narasimhan, D.,Collins, G.T.,Nance, M.R.,Nichols, J.,Edwald, E.,Chan, J.,Ko, M.C.,Woods, J.H.,Tesmer, J.J.,Sunahara, R.K.
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80:1056-1065, 2011
PubMed: 21890748 (PDB entries with the same primary citation)
DOI: 10.1124/mol.111.074997
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.250102.0%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload