Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0050784 | biological_process | cocaine catabolic process |
A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0008239 | molecular_function | dipeptidyl-peptidase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0050784 | biological_process | cocaine catabolic process |
B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 588 |
Chain | Residue |
A | ASN197 |
A | VAL199 |
A | PHE408 |
A | HIS409 |
A | ASN410 |
A | HOH657 |
A | HOH740 |
B | ARG293 |
B | LYS298 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 589 |
Chain | Residue |
A | VAL554 |
A | ARG556 |
A | HOH707 |
A | HOH972 |
B | SER452 |
B | SER454 |
B | VAL554 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 A 590 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 591 |
Chain | Residue |
A | ASP296 |
B | ASP296 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 592 |
Chain | Residue |
A | ASP319 |
A | ARG323 |
A | GLU325 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 588 |
Chain | Residue |
A | ARG293 |
A | LYS298 |
B | LEU196 |
B | VAL199 |
B | PHE408 |
B | HIS409 |
B | ASN410 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 589 |
Chain | Residue |
B | ASP65 |
B | ASP319 |
B | GLU325 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | SER117 | |
B | SER117 | |
Chain | Residue | Details |
A | ASP259 | |
A | HIS287 | |
B | ASP259 | |
B | HIS287 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | TYR44 | |
A | TYR118 | |
B | TYR44 | |
B | TYR118 | |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Probably involved in activating the substrate carbonyl and the acyl enzyme for hydrolysis |
Chain | Residue | Details |
A | TYR44 | |
B | TYR44 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 465 |
Chain | Residue | Details |
A | TYR44 | transition state stabiliser |
A | SER117 | covalent catalysis, proton shuttle (general acid/base) |
A | TYR118 | electrostatic stabiliser |
A | TRP166 | activator |
A | ASP259 | activator, electrostatic stabiliser |
A | HIS287 | proton shuttle (general acid/base) |
site_id | MCSA2 |
Number of Residues | 6 |
Details | M-CSA 465 |
Chain | Residue | Details |
B | TYR44 | transition state stabiliser |
B | SER117 | covalent catalysis, proton shuttle (general acid/base) |
B | TYR118 | electrostatic stabiliser |
B | TRP166 | activator |
B | ASP259 | activator, electrostatic stabiliser |
B | HIS287 | proton shuttle (general acid/base) |