Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0050784 | biological_process | cocaine catabolic process |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0050784 | biological_process | cocaine catabolic process |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 588 |
| Chain | Residue |
| A | ASN197 |
| A | VAL199 |
| A | PHE408 |
| A | HIS409 |
| A | ASN410 |
| A | HOH657 |
| A | HOH740 |
| B | ARG293 |
| B | LYS298 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 589 |
| Chain | Residue |
| A | VAL554 |
| A | ARG556 |
| A | HOH707 |
| A | HOH972 |
| B | SER452 |
| B | SER454 |
| B | VAL554 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 590 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 591 |
| Chain | Residue |
| A | ASP296 |
| B | ASP296 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 592 |
| Chain | Residue |
| A | ASP319 |
| A | ARG323 |
| A | GLU325 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 588 |
| Chain | Residue |
| A | ARG293 |
| A | LYS298 |
| B | LEU196 |
| B | VAL199 |
| B | PHE408 |
| B | HIS409 |
| B | ASN410 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 589 |
| Chain | Residue |
| B | ASP65 |
| B | ASP319 |
| B | GLU325 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | SER117 | |
| B | SER117 | |
| Chain | Residue | Details |
| A | ASP259 | |
| A | HIS287 | |
| B | ASP259 | |
| B | HIS287 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TYR44 | |
| A | TYR118 | |
| B | TYR44 | |
| B | TYR118 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Probably involved in activating the substrate carbonyl and the acyl enzyme for hydrolysis |
| Chain | Residue | Details |
| A | TYR44 | |
| B | TYR44 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 465 |
| Chain | Residue | Details |
| A | TYR44 | transition state stabiliser |
| A | SER117 | covalent catalysis, proton shuttle (general acid/base) |
| A | TYR118 | electrostatic stabiliser |
| A | TRP166 | activator |
| A | ASP259 | activator, electrostatic stabiliser |
| A | HIS287 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 465 |
| Chain | Residue | Details |
| B | TYR44 | transition state stabiliser |
| B | SER117 | covalent catalysis, proton shuttle (general acid/base) |
| B | TYR118 | electrostatic stabiliser |
| B | TRP166 | activator |
| B | ASP259 | activator, electrostatic stabiliser |
| B | HIS287 | proton shuttle (general acid/base) |
