7XK9

Structure of human beta2 adrenergic receptor bound to constrained isoproterenol

Summary for 7XK9

• Entry DOI: 10.2210/pdb7xk9/pdb
• Descriptor: Endolysin,Beta-2 adrenergic receptor, Camelid Antibody Fragment, (5R,6R)-6-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, ... (4 entities in total)
• Functional Keywords: gpcr, membrane protein
• Biological source: Enterobacteria phage T4 (Bacteriophage T4); More
• Total number of polymer chains: 2
• Total formula weight: 66680.70

Authors

Xu, X.,Shonberg, J.,Kaindl, J.,Clark, M.,Stobel, A.,Maul, L.,Mayer, D.,Hubner, H.,Venkatakrishnan, A.,Dror, R.,Kobilka, B.K.,Sunahara, R.,Liu, X.,Gmeiner, P. (deposition date: 2022-04-19, release date: 2023-04-26, Last modification date: 2023-11-29)

• Primary citation: Xu, X.,Shonberg, J.,Kaindl, J.,Clark, M.J.,Stossel, A.,Maul, L.,Mayer, D.,Hubner, H.,Hirata, K.,Venkatakrishnan, A.J.,Dror, R.O.,Kobilka, B.K.,Sunahara, R.K.,Liu, X.,Gmeiner, P.; Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.; Nat Commun, 14:2138-2138, 2023; PubMed: 37059717; DOI: 10.1038/s41467-023-37808-y

Experimental method

X-RAY DIFFRACTION (3.4 Å)